The flu vaccine is a vaccine to protect against the highly variable influenza virus.
The annually updated trivalent flu vaccine for the 2005-2006 season consists of hemagglutinin (HA) surface glycoprotein components from influenza H3N2, H1N1, and B influenza viruses.
Each year the influenza virus changes and different strains become dominant.
Due to the high mutability of the virus a particular vaccine formulation usually only works for about a year..
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