Reference Article

from Wikipedia, the free encyclopedia


Myosins are a large family of motor proteins found in eukaryotic tissues.

They are responsible for actin-based motility.

Most myosin molecules are composed of both a head and a tail domain.

The head domain binds the filamentous actin, and uses ATP hydrolysis to generate force and to "walk" along the filament towards the (+) end (with the exception of one family member, myosin VI, which moves towards the (-) end).

The tail domain generally mediates interaction with cargo molecules and/or other myosin subunits.

Myosin II, responsible for skeletal muscle contraction, is perhaps the best-studied example of these properties.

In muscle cells, it is myosin II that is responsible for producing the contractile force.

Note: This article excerpts material from the Wikipedia article "Myosin", which is released under the GNU Free Documentation License.

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