A peptide bond is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule, releasing a molecule of water (H2O).

This is a dehydration synthesis reaction (also known as a condensation reaction), and usually occurs between amino acids.

The resulting CO-NH bond is called a peptide bond, and the resulting molecule is an amide.

The four-atom functional group -C(=O)NH- is called an amide group or (in the context of proteins) a peptide group.

Polypeptides and proteins are chains of amino acids held together by peptide bonds, as is the backbone of PNA..

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