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PARP Inhibitors May Have Clinical Utility in HER2-Positive Breast Cancers
September 17, 2012 — Poly (ADP-Ribose) polymerase (PARP) inhibitors, shown to have clinical activity when used alone in women with familial breast and ovarian cancers linked to BRCA mutations, may be a novel treatment ... > full story -
Lack of Oxygen in Cancer Cells Leads to Growth and Metastasis
September 13, 2012 — The proteins HIF-1a and CD24 have both been implicated in the aggressive characteristics of hypoxic cancers. A new study shows that HIF-1a drives CD24 overexpression, and that CD24 then drives ... > full story -
Novel Therapeutic Targets Identified for Small Cell Lung Cancer
September 6, 2012 — • If validated, may have the potential to produce first targeted therapy for this disease. • Molecular profile of small cell lung cancer distinct from nonsmall cell lung ... > full story -
Ovarian Cancer Cells Hijack Surrounding Tissues to Enhance Tumor Growth
September 4, 2012 — Researchers have discovered that ovarian cancer cells activate the HOXA9 gene to compel stromal cells to create an environment that supports tumor ... > full story -
Mechanisms of Acquired Chemoresistance in Ovarian Cancer Identified
August 15, 2012 — Disease has high heterogeneity. First-line chemosensitivity associated with subsequent chemoresistance. Gene identified that may predict ... > full story -
First-of-Its-Kind Approach Nanomedicine Design Effectively Targets Cancer With Decreased Toxicity
July 10, 2012 — A new approach that integrates rational drug design with supramolecular nanochemistry in cancer treatment has just been ... > full story -
Unexpected Discovery Highlights New Role for Cell Death Regulator
June 14, 2012 — Scientists have already revealed the mechanism by which high alcohol intake can induce pancreatitis and its progression to pancreatic cancer. Now a new study reveals a hitherto unknown interaction ... > full story -
Marked for Destruction: Newly Developed Compound Triggers Cancer Cell Death
May 24, 2012 — Scientists have developed a compound that enhance cell death in cancer ... > full story -
DNA Marker Indicates If Ovarian Cancer Treatment Will Be Successful, Study Suggests
April 3, 2012 — Researchers have discovered that blood can help determine the best treatment plan for patients with ovarian ... > full story -
Cancer Stem Cell Vaccine in Development Shows Antitumor Effect
April 2, 2012 — Stem cells had greater effect than differentiated tumor cells in eliciting antitumor immunity in vivo. Antibodies and T cells targeted cancer stem cells in laboratory models. Data could provide a ... > full story
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