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Gene Therapy For Addiction: Flooding Brain With 'Pleasure Chemical' Receptors Works On Cocaine, As On Alcohol
April 16, 2008 — Increasing the brain level of receptors for dopamine, a pleasure-related chemical, can reduce use of cocaine by 75 percent in rats trained to self-administer it. Earlier research had similar findings ... > full story -
Animal Research Suggests Long-Term Effects Of Fetal Cocaine Exposure
April 7, 2008 — Are the estimated 1 million young adults who were exposed to cocaine before birth more vulnerable to drug abuse today? New research indicating long-lasting brain changes suggests the possibility -- ... > full story -
Prenatal Exposure To Drugs, Alcohol And Tobacco Affect The Brain Into Early Adolescence, Scans Show
April 7, 2008 — Over 1 million babies born annually in the United States are exposed to drugs, alcohol or tobacco while in utero. New research suggests that prenatal exposure to these substances (alone or in ... > full story -
Subordinate Monkeys More Likely To Choose Cocaine Over Food
April 6, 2008 — Having a lower social standing increases the likelihood that a monkey faced with a stressful situation will choose cocaine over food, according to a new study. More dominant monkeys undergoing the ... > full story -
New Strategy For Treating Cocaine Addiction, Animal Research Suggests
April 6, 2008 — New research in monkeys suggests the feasibility of treating cocaine addiction with a "replacement" drug that mimics the effects of cocaine but has less potential for abuse -- similar to the way ... > full story -
Environmental Enrichment Can Reduce Cocaine Use, Researchers Find
April 6, 2008 — Simple environmental enrichment and increased social stress can both affect the level of individual drug use, according to new monkey research. Enrichment reduced drug use by all of the study ... > full story -
Emotional 'Bummer' Of Cocaine Addiction Mimicked In Animals
March 12, 2008 — Cocaine addicts often suffer a downward emotional spiral that is a key to their craving and chronic relapse. While researchers have developed animal models of the reward of cocaine, they have not ... > full story -
Common Heart Drug May Reduce Cocaine Cravings
February 27, 2008 — Diltiazem, a drug used in the treatment of high blood pressure, reduces cocaine cravings in a rat model. Previous work showed that two brain chemicals, dopamine and glutamate, independently ... > full story -
Cocaine's Effects On Brain Metabolism May Contribute To Abuse
February 18, 2008 — Many studies on cocaine addiction - and attempts to block its addictiveness - have focused on dopamine transporters, proteins that reabsorb the brain's "reward" chemical once its signal is sent. ... > full story -
Brain Circuitry That Drives Drug-Seeking Compulsion Identified
February 6, 2008 — In experiments with rats, researchers have identified the change in brain circuitry that drives development of a compulsion to seek drugs, even when that compulsion is self-destructive. The ... > full story
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