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First Analysis of Tumor-Suppressor Interactions With Whole Genome in Normal Human Cells Reveals Key Differences With Cancer Cells
November 30, 2011 — Scientists investigating the interactions, or binding patterns, of a major tumor-suppressor protein known as p53 with the entire genome in normal human cells have turned up key differences from those ... > full story -
Tamoxifen Resistance -- And How to Defeat It
November 13, 2011 — In the last three decades, thousands of women with breast cancer have taken the drug tamoxifen, only to discover that the therapy doesn't work, either because their tumors do not respond to the ... > full storyMore: -
Combination 'Epigenetic' Therapy May Restore Anti-Cancer Gene Activity in Late-Stage Lung Cancer Patients
November 10, 2011 — A new type of therapy aimed at reversing the gene-silencing that promotes cancer-cell growth has shown promising results in a small clinical trial. Forty-five late-stage lung cancer patients who ... > full storyMore: -
Study Characterizes Epigenetic Signatures of Autism in Brain Tissue
November 7, 2011 — Neurons in the prefrontal cortex of individuals with autism show changes at numerous sites across the genome, according to a new ... > full story -
Chromosome Centromeres Are Inherited Epigenetically
November 3, 2011 — The histone protein CenH3 is both necessary and sufficient to trigger the formation of centromeres and pass them on from one generation to the ... > full story -
Patterns of New DNA Letter in Brain Suggest Distinct Function
October 30, 2011 — In 2009, the DNA alphabet expanded. Scientists discovered that an extra letter or "sixth nucleotide" was surprisingly abundant in DNA from stem cells and brain cells. Now, researchers have mapped the ... > full story -
Propensity for Longer Life Span Inherited Non-Genetically Over Generations, Study Shows
October 20, 2011 — We know that our environment -- what we eat, the toxic compounds we are exposed to -- can positively or negatively impact our life span. But could it also affect the longevity of our descendants, who ... > full story -
Scientists Discover 'Fickle' DNA Changes in Brain
September 30, 2011 — Scientists investigating chemical modifications across the genomes of adult mice have discovered that DNA modifications in non-dividing brain cells, thought to be inherently stable, instead underwent ... > full story -
Novel Technique Reveals Both Gene Number and Protein Expression Simultaneously
September 22, 2011 — Researchers have discovered a method to simultaneously measure gene number and protein expression in individual cells. The fluorescence microscopy technique could permit a detailed analysis of the ... > full story -
Twin Study Reveals Epigenetic Alterations of Psychiatric Disorders
September 21, 2011 — In the first study to systematically investigate genome-wide epigenetic differences in a large number of psychosis discordant twin-pairs, new research provides further evidence that epigenetic ... > full story
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