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Large DNA Stretches, Not Single Genes, Shut Off As Cells Mature
January 18, 2009 — The gradual maturing of embryonic cells into cells as varied as brain, liver and immune system cells is apparently due to the shut off of several genes at once rather than in individual smatterings ... > full story -
Growth Of New Brain Cells Requires 'Epigenetic' Switch
January 8, 2009 — New cells are born every day in the brain's hippocampus, but what controls this birth has remained a mystery. Neuroscientists have now discovered that the birth of new cells, which depends on brain ... > full story -
In Lung Cancer, Silencing One Crucial Gene Disrupts Normal Functioning Of Genome
December 31, 2008 — While examining patterns of DNA modification in lung cancer, scientists have discovered what they say is a surprising new mechanism. They say that "silencing" of a single gene in lung cancer led to a ... > full story -
Tracking The Molecular Pathway To Mixed-Lineage Leukemia
December 15, 2008 — The MLL-AF4 fusion protein, which causes the blood cancer called mixed-lineage leukemia, binds to several genes responsible for early blood cell development. MLL-AF4 also alters the chromatin ... > full story -
Work With Fungus Uncovering Keys To DNA Methylation
December 15, 2008 — Researchers have made progress on understanding biochemical communications among proteins involved in gene silencing. They have shed more light on the mechanism that regulates DNA methylation, a ... > full story -
Why Are Some People More Susceptible To Depression Than Others? Stressed-out Mice Reveal Role Of Epigenetics In Behavior
December 11, 2008 — Research conducted by a team in Switzerland suggests that a family of genes involved in regulating the expression of other genes in the brain is responsible for helping us deal with external inputs ... > full story -
Changing Epigenetic Modifications That Enable Transposons To Run Amok
December 10, 2008 — Changes in gene activity allow cells to cope with environmental changes but leave genes prone to mis-regulation by transposons -- bits of DNA that jump around the genome, often disrupting normal gene ... > full story -
Novel Histone Demethylase Protein Complex Discovered
December 5, 2008 — Scientists have discovered a novel histone demethylase protein complex characterized in work published in Molecular ... > full story -
Large-Scale Gene Silencing Mystery Solved
December 4, 2008 — Scientists have made a breakthrough in understanding the phenomenon of nucleolar dominance, the silencing of an entire parental set of ribosomal RNA genes in a hybrid plant or animal. Since the ... > full story -
Epigenetics: Plants Display 'Molecular Amnesia'
December 2, 2008 — Plant researchers have announced a major breakthrough in a developmental process called epigenetics. They have demonstrated for the first time the reversal of what is called epigenetic silencing in ... > full story
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