Featured Research

from universities, journals, and other organizations

Minor Leg Injuries Associated With Risk Of Blood Clots

Date:
January 15, 2008
Source:
JAMA and Archives Journals
Summary:
Muscle ruptures, ankle sprains and other common minor leg injuries appear to be associated with a higher risk for blood clots in the legs or lungs, according to a new article. Previous studies have shown that major injuries increase the risk for venous thrombosis.

Muscle ruptures, ankle sprains and other common minor leg injuries appear to be associated with a higher risk for blood clots in the legs or lungs, according to a new article.

Related Articles


Previous studies have shown that major injuries increase the risk for venous thrombosis, according to background information in the article. This disorder includes deep vein thrombosis, or blood clots in the leg, and pulmonary embolism, or a blood clot that has traveled to the lungs,. "However, apart from the injury itself, other risk factors for venous thrombosis will be present because of the major injury, such as surgery, a plaster cast, hospitalization and extended bed rest," the authors write. "The risk of so-called minor injuries that do not lead to these additional factors is unknown."

Karlijn J. van Stralen, M.Sc., and colleagues at Leiden University Medical Center, Leiden, the Netherlands, studied 2,471 patients who developed venous thrombosis between 1999 and 2004. The patients completed a questionnaire about any injuries, surgical procedures, plaster casts or immobilizations they had within one year of developing blood clots, as well as their height, weight, family history and sports participation. These patients were compared with 3,534 controls who did not have venous thrombosis, recruited by inviting partners of the patients to participate as well as using a random-digit--dialing method.

A total of 289 patients (11.7 percent) had a minor injury in the three months prior to developing venous thrombosis, while 154 controls (4.4 percent) had a minor injury in the three months before completing the questionnaire. "Minor injuries that do not require surgery, a plaster cast or extended bed rest were associated with a three-fold greater relative risk of venous thrombosis," the authors write. "The association appeared local because injuries in the leg were associated strongly with thrombosis, while injuries in other locations were not associated with thrombosis. The association was strongest for injuries that occurred in the month before the venous thrombosis, suggesting a transient effect." The association was also stronger in individuals with genetic or other risk factors for blood clots.

There are several reasons such injuries may increase the risk of blood clots, the authors note. Even injuries that do not require an individual to be completely immobilized may cause them to be less active, potentially leading to blood clots. In addition, damage to the blood vessel wall from an injury also could increase clotting risk in the affected area.

"Because minor injuries are common, they can be major contributors to the occurrence of venous thrombosis," the authors conclude. "Many individuals with minor injuries will have contacted the general practitioner first. Therefore, there may be an important task for general practitioners to identify subjects who are at high risk of developing venous thrombosis and subsequently to provide prophylactic measures."

Journal reference: Arch Intern Med. 2008;168[1]:21-26.

This study was supported by a grant from the Netherlands Heart Foundation, a grant from the Dutch Cancer Foundation and a grant from the Netherlands Organisation for Scientific Research.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Minor Leg Injuries Associated With Risk Of Blood Clots." ScienceDaily. ScienceDaily, 15 January 2008. <www.sciencedaily.com/releases/2008/01/080114162529.htm>.
JAMA and Archives Journals. (2008, January 15). Minor Leg Injuries Associated With Risk Of Blood Clots. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2008/01/080114162529.htm
JAMA and Archives Journals. "Minor Leg Injuries Associated With Risk Of Blood Clots." ScienceDaily. www.sciencedaily.com/releases/2008/01/080114162529.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins