Featured Research

from universities, journals, and other organizations

Aged, damaged hearts yield stem cells that could treat heart failure, research suggests

Date:
November 21, 2010
Source:
American Heart Association
Summary:
Ample and viable cardiac stem cells can be isolated from elderly and sick patients with heart disease and diabetes, new research suggests. It may be possible to treat heart failure patients with their own stem cells. An unrelated study notes that an aging heart can generate new cells at a substantial rate.

Cardiac stem cells -- even in elderly and sick patients -- could generate new heart muscle and vessel tissue and be used to treat heart failure, according to research presented at the American Heart Association's Scientific Sessions 2010.

Scientists surgically removed tissue from the muscular wall of the heart's chambers in 21 patients. They then isolated and multiplied the cardiac stem cells (CSCs) found there. Most of the patients had ischemic cardiomyopathy (enlarged and weakened muscle due to coronary artery disease). Eleven also had diabetes. The average age of patients was about 65.

"Regardless of the gender or age of the patient, or of diabetes, we were able to isolate in all of them a pool of functional cardiac stem cells that we can potentially use to rescue the decompensated human heart," said Domenico D'Amario, M.D., Ph.D., author of the study and a postdoctoral fellow at the Center for Regenerative Medicine at Harvard, Boston, Mass.

Among the 12 female and nine male patients, researchers obtained 20 percent more CSCs from the hearts of the women than the men. Age or diabetes status didn't affect the number of cells harvested.

Women have a longer life span than men, and even with heart failure their hearts generally show more resilience -- possibly explaining the researchers' finding, D'Amario said.

The researchers also examined stem cells' biological properties that would influence their therapeutic value. They found that cells had long telomeres, or "caps," on their chromosomal ends indicating that expanded CSCs retained a significant growth reserve, although less so in older or diabetic patients.

On the same study, scientists also studied activation of a cell surface marker, insulin growth factor receptor 1 (IGF-1R), which recognizes stem cells that are most likely to thrive and have the potential to produce new cardiac tissue.

"Now you have a resident cardiac stem cell that is already programmed to form cardiac muscle, so this cell is already superior to any other cell you can take from other tissues," said Piero Anversa, M.D., senior author of the study and director of the Center for Regenerative Medicine.

CSCs are distributed throughout the cardiac muscle, but the atrial and apical regions of the heart contain niches, where the cells are protected from the physical stress of the heartbeat.

The heart's CSC reserve is present regardless of patient differences in ethnicity, background, diet and other factors. Research in more patients is needed to bolster the strength of the data, Anversa said.

Other co-authors are: Konrad Urbanek, M.D.; Toru Hosoda, M.D., Ph.D.; Hanqiao Zheng, M.D.; Annarosa Leri, M.D.; Erik Sylvin, M.D.; David D'Alessandro, M.D.; Robert E. Michler, M.D.; Jan Kajstura, Ph.D.; Filippo Crea, M.D.; Roberto Bolli, M.D.; Piero Anversa, M.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Aged, damaged hearts yield stem cells that could treat heart failure, research suggests." ScienceDaily. ScienceDaily, 21 November 2010. <www.sciencedaily.com/releases/2010/11/101117104450.htm>.
American Heart Association. (2010, November 21). Aged, damaged hearts yield stem cells that could treat heart failure, research suggests. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/11/101117104450.htm
American Heart Association. "Aged, damaged hearts yield stem cells that could treat heart failure, research suggests." ScienceDaily. www.sciencedaily.com/releases/2010/11/101117104450.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins