Featured Research

from universities, journals, and other organizations

Aged, damaged hearts yield stem cells that could treat heart failure, research suggests

Date:
November 21, 2010
Source:
American Heart Association
Summary:
Ample and viable cardiac stem cells can be isolated from elderly and sick patients with heart disease and diabetes, new research suggests. It may be possible to treat heart failure patients with their own stem cells. An unrelated study notes that an aging heart can generate new cells at a substantial rate.

Cardiac stem cells -- even in elderly and sick patients -- could generate new heart muscle and vessel tissue and be used to treat heart failure, according to research presented at the American Heart Association's Scientific Sessions 2010.

Scientists surgically removed tissue from the muscular wall of the heart's chambers in 21 patients. They then isolated and multiplied the cardiac stem cells (CSCs) found there. Most of the patients had ischemic cardiomyopathy (enlarged and weakened muscle due to coronary artery disease). Eleven also had diabetes. The average age of patients was about 65.

"Regardless of the gender or age of the patient, or of diabetes, we were able to isolate in all of them a pool of functional cardiac stem cells that we can potentially use to rescue the decompensated human heart," said Domenico D'Amario, M.D., Ph.D., author of the study and a postdoctoral fellow at the Center for Regenerative Medicine at Harvard, Boston, Mass.

Among the 12 female and nine male patients, researchers obtained 20 percent more CSCs from the hearts of the women than the men. Age or diabetes status didn't affect the number of cells harvested.

Women have a longer life span than men, and even with heart failure their hearts generally show more resilience -- possibly explaining the researchers' finding, D'Amario said.

The researchers also examined stem cells' biological properties that would influence their therapeutic value. They found that cells had long telomeres, or "caps," on their chromosomal ends indicating that expanded CSCs retained a significant growth reserve, although less so in older or diabetic patients.

On the same study, scientists also studied activation of a cell surface marker, insulin growth factor receptor 1 (IGF-1R), which recognizes stem cells that are most likely to thrive and have the potential to produce new cardiac tissue.

"Now you have a resident cardiac stem cell that is already programmed to form cardiac muscle, so this cell is already superior to any other cell you can take from other tissues," said Piero Anversa, M.D., senior author of the study and director of the Center for Regenerative Medicine.

CSCs are distributed throughout the cardiac muscle, but the atrial and apical regions of the heart contain niches, where the cells are protected from the physical stress of the heartbeat.

The heart's CSC reserve is present regardless of patient differences in ethnicity, background, diet and other factors. Research in more patients is needed to bolster the strength of the data, Anversa said.

Other co-authors are: Konrad Urbanek, M.D.; Toru Hosoda, M.D., Ph.D.; Hanqiao Zheng, M.D.; Annarosa Leri, M.D.; Erik Sylvin, M.D.; David D'Alessandro, M.D.; Robert E. Michler, M.D.; Jan Kajstura, Ph.D.; Filippo Crea, M.D.; Roberto Bolli, M.D.; Piero Anversa, M.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Aged, damaged hearts yield stem cells that could treat heart failure, research suggests." ScienceDaily. ScienceDaily, 21 November 2010. <www.sciencedaily.com/releases/2010/11/101117104450.htm>.
American Heart Association. (2010, November 21). Aged, damaged hearts yield stem cells that could treat heart failure, research suggests. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2010/11/101117104450.htm
American Heart Association. "Aged, damaged hearts yield stem cells that could treat heart failure, research suggests." ScienceDaily. www.sciencedaily.com/releases/2010/11/101117104450.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins