Featured Research

from universities, journals, and other organizations

Human lung stem cell discovered: Crucial role in tissue regeneration

Date:
May 12, 2011
Source:
Brigham and Women's Hospital
Summary:
For the first time, researchers have identified a human lung stem cell that is self-renewing and capable of forming and integrating multiple biological structures of the lung including bronchioles, alveoli and pulmonary vessels.

For the first time, researchers at Brigham and Women's Hospital (BWH) have identified a human lung stem cell that is self-renewing and capable of forming and integrating multiple biological structures of the lung including bronchioles, alveoli and pulmonary vessels. This research is published in the May 12, 2011 issue of the New England Journal of Medicine.

Related Articles


"This research describes, for the first time, a true human lung stem cell. The discovery of this stem cell has the potential to offer those who suffer from chronic lung diseases a totally novel treatment option by regenerating or repairing damaged areas of the lung," said Piero Anversa, MD, director of the Center for Regenerative Medicine at Brigham and Women's Hospital and corresponding author.

Using lung tissue from surgical samples, researchers identified and isolated the human lung stem cell and tested the functionality of the stem cell both in vitro and in vivo. Once the stem cell was isolated, researchers demonstrated in vitro that the cell was capable of dividing both into new stem cells and also into cells that would grow into various types of lung tissue. Next, researchers injected the stem cell into mice with damaged lungs. The injected stem cells differentiated into new bronchioles, alveoli and pulmonary vessel cells which not only formed new lung tissue, but also integrated structurally to the existing lung tissue in the mice.

The researchers define this cell as truly "stem" because it fulfills the three categories necessary to fall under stem cell categorization: first, the cell renews itself; second, it forms into many different types of lung cells; and third, it is transmissible, meaning that after a mouse was injected with the stem cells and responded by generating new tissue, researchers were then able to isolate the stem cell in the treated mouse, and use that cell in a new mouse with the same results.

"These are the critical first steps in developing clinical treatments for those with lung disease for which no therapies exist. Further research is needed, but we are excited about the impact this discovery could have on our ability to regenerate or recreate new lung tissues to replace damaged areas of the lungs," said Joseph Loscalzo, MD, PhD, chair of the Department of Medicine at BWH and co-author.

This research was funded through grants from the National Institutes of Health (NIH).


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jan Kajstura, Marcello Rota, Sean R. Hall, Toru Hosoda, Domenico D'Amario, Fumihiro Sanada, Hanqiao Zheng, Barbara Ogórek, Carlos Rondon-Clavo, Joăo Ferreira-Martins, Alex Matsuda, Christian Arranto, Polina Goichberg, Giovanna Giordano, Kathleen J. Haley, Silvana Bardelli, Hussein Rayatzadeh, Xiaoli Liu, Federico Quaini, Ronglih Liao, Annarosa Leri, Mark A. Perrella, Joseph Loscalzo, Piero Anversa. Evidence for Human Lung Stem Cells. New England Journal of Medicine, 2011; 364 (19): 1795 DOI: 10.1056/NEJMoa1101324

Cite This Page:

Brigham and Women's Hospital. "Human lung stem cell discovered: Crucial role in tissue regeneration." ScienceDaily. ScienceDaily, 12 May 2011. <www.sciencedaily.com/releases/2011/05/110511170837.htm>.
Brigham and Women's Hospital. (2011, May 12). Human lung stem cell discovered: Crucial role in tissue regeneration. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2011/05/110511170837.htm
Brigham and Women's Hospital. "Human lung stem cell discovered: Crucial role in tissue regeneration." ScienceDaily. www.sciencedaily.com/releases/2011/05/110511170837.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins