Featured Research

from universities, journals, and other organizations

Common invasive test not necessary for kidney disease patients, study finds; Clinicians can monitor kidney function with a simple equation

Date:
September 15, 2011
Source:
American Society of Nephrology
Summary:
Equations that estimate a patient's kidney function work as well as direct, invasive measurements, according to a new study. This means that many patients with chronic kidney disease (CKD) do not need to undergo the painful and cumbersome procedures that are performed to monitor kidneys' health.

Equations that estimate a patient's kidney function work as well as direct, invasive measurements, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). This means that many patients with chronic kidney disease (CKD) do not need to undergo the painful and cumbersome procedures that are performed to monitor kidneys' health.

Measuring CKD patients' kidney function can help physicians anticipate complications and provide optimal treatments. Most measures focus on patients' glomerular filtration rate (GFR), or the rate that the kidneys filter wastes from the urine. Clinicians have traditionally assumed that directly testing GFR by injecting a tracer agent such as iothalamate provides a better measure of kidney function than calculating GFR indirectly with an equation. However, iothalamate GFR (iGFR) is more cumbersome and invasive than equation-estimated GFR (eGFR). Specifically, iGFR involves injecting a (sometimes radioactive) agent, taking multiple blood samples, and doing timed urine collections, while eGFR involves one simple blood test.

To compare the tests, Chi-yuan Hsu, MD (University of California, San Francisco) and his colleagues looked to see which is more strongly and consistently linked with common CKD complications in 1,214 CKD patients who participated in the Chronic Renal Insufficiency Cohort (CRIC) study, which includes the largest ever group of CKD patients assembled and is sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases.

The investigators found that eGFR linked just as tightly to CKD complications as iGFR. These results refute the conventional view that iGFR is in fact the gold standard measure of kidney function. "For many purposes and for many patients, relying on equations to estimate GFR alone may be sufficient, and patients can avoid undergoing more invasive assays to directly measure GFR," said Dr. Hsu.

Approximately 60 million people globally have CKD. Early detection and treatment can prevent kidney failure, but individuals with the disease often do not experience symptoms until later stages.

Study co-authors include Kathleen Propert, PhD, Dawei Xie, PhD, Valerie Teal, Raymond Townsend, MD, Harold Feldman, MD (University of Pennsylvania); Lee Hamm, MD, Jiang He, MD, PhD (Tulane University); Edgar Miller, MD (Johns Hopkins University); Akinlolu Ojo, MD, PhD, Jillian Wilson (University of Michigan, Ann Arbor); Michael Shlipak, MD (University of California, San Francisco); and Matthew Weir, MD (University of Maryland).


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chi-Yuan Hsu, Kathleen Propert, Dawei Xie, Lee Hamm, Jiang He, Edgar Miller, Akinlolu Ojo, Michael Shlipak, Valerie Teal, Raymond Townsend, Matthew Weir, Jillian Wilson, Harold Feldman, for the CRIC Investigators. Measured GFR Does Not Outperform Estimated GFR in Predicting CKD-related Complications. Journal of the American Society Nephrology, 2011; DOI: 10.1681/ASN.2010101077

Cite This Page:

American Society of Nephrology. "Common invasive test not necessary for kidney disease patients, study finds; Clinicians can monitor kidney function with a simple equation." ScienceDaily. ScienceDaily, 15 September 2011. <www.sciencedaily.com/releases/2011/09/110915171627.htm>.
American Society of Nephrology. (2011, September 15). Common invasive test not necessary for kidney disease patients, study finds; Clinicians can monitor kidney function with a simple equation. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2011/09/110915171627.htm
American Society of Nephrology. "Common invasive test not necessary for kidney disease patients, study finds; Clinicians can monitor kidney function with a simple equation." ScienceDaily. www.sciencedaily.com/releases/2011/09/110915171627.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins