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Broccoli-based compound beats drug resistance in lung disease

Date:
October 17, 2011
Source:
Journal of Clinical Investigation
Summary:
Chronic obstructive pulmonary disease (COPD) is a common lung disease that gets progressively worse over time. Inflammation has a central role in driving COPD. However, patients derive little benefit from treatment with potent anti-inflammatory drugs known as corticosteroids. Now, researchers have identified a candidate therapeutic that could potentially be used to augment the anti-inflammatory effects of corticosteroids in individuals with COPD -- a compound obtained from cruciferous vegetables.

Chronic obstructive pulmonary disease (COPD) is a common lung disease that gets progressively worse over time, making it harder and harder to breathe. It is caused primarily by cigarette smoking, which leads to persistent inflammation in the airways and the subsequent destruction of the lung tissue.

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Given the central role of inflammation in COPD, it is surprising that patients derive little benefit from treatment with potent anti-inflammatory drugs known as corticosteroids.

Working with cells from individuals with COPD, a team of researchers led by Shyam Biswal and Rajesh Thimmulappa, at Johns Hopkins University, Baltimore, has identified a candidate therapeutic that could potentially be used to augment the anti-inflammatory effects of corticosteroids in individuals with COPD -- sulforaphane, a compound obtained from cruciferous vegetables such as broccoli, Brussels sprouts, and cabbages.

The research is published in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Deepti Malhotra, Rajesh K. Thimmulappa, Nicolas Mercado, Kazuhiro Ito, Ponvijay Kombairaju, Sarvesh Kumar, Jinfang Ma, David Feller-Kopman, Robert Wise, Peter Barnes, Shyam Biswal. Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI45144

Cite This Page:

Journal of Clinical Investigation. "Broccoli-based compound beats drug resistance in lung disease." ScienceDaily. ScienceDaily, 17 October 2011. <www.sciencedaily.com/releases/2011/10/111017124251.htm>.
Journal of Clinical Investigation. (2011, October 17). Broccoli-based compound beats drug resistance in lung disease. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2011/10/111017124251.htm
Journal of Clinical Investigation. "Broccoli-based compound beats drug resistance in lung disease." ScienceDaily. www.sciencedaily.com/releases/2011/10/111017124251.htm (accessed April 18, 2015).

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Oct. 18, 2011 Corticosteroids do not improve survival nor alter the progression of COPD and may reduce lung symptoms as little as 20 percent. A new study found why corticosteroids do not work well for COPD ... read more

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