Featured Research

from universities, journals, and other organizations

Low-calorie diet may be harmful for bowel disease patients

Date:
March 20, 2012
Source:
Michigan State University
Summary:
In a surprising result, researchers looking at the effects of diet on bowel disease found that mice on a calorie-restricted diet were more likely to die after being infected with an inflammation-causing bacterial pathogen in the colon.

In a surprising result, Michigan State University researchers looking at the effects of diet on bowel disease found that mice on a calorie-restricted diet were more likely to die after being infected with an inflammation-causing bacterial pathogen in the colon.

Related Articles


While research suggests inflammation associated with obesity may contribute to inflammatory bowel diseases such as colitis, the study results revealed a low-calorie diet may actually impair the immune system's ability to respond to infection, said Jenifer Fenton, assistant professor in the Department of Food Science and Human Nutrition.

Additionally, the study found no connection that moderate obesity increased the severity of colitis in the mouse model.

"The results are similar to the research from our department that shows consuming fewer calories make it harder to fight off the flu virus," said Fenton, referring to recent work by colleague Elizabeth Gardner. "Since this is a totally different pathogen, it amplifies the need to find out why caloric intake has such an impact on the body's ability to respond to infection.

"It is possible that the same mechanism that happens with the flu is occurring with gastro-intestinal diseases; future research will ask this very question."

The research is published in the current edition of the World Journal of Gastroenterology.

Inflammatory bowel disease, or IBD, is a group of conditions affecting the colon and intestines; the major types being ulcerative colitis and Crohn's disease. People suffering from IBD have an increased risk of developing colon cancer.

As part of their study, Fenton and colleagues evaluated the influence of obesity and calorie-restricted diets on mice with induced colitis.

Mice in the study were given one of three dietary treatments: a high-fat diet, a 30 percent caloric-restriction diet and a control group on an average-caloric diet. They then were treated with bacteria called H. hepaticus, which infects the colon and causes inflammation, eventually leading to tumor development. This process models the more aggressive lesions observed in human colon cancer cases.

Unexpectedly, study results suggest increased body fat induced by a high-fat diet did not influence the severity of colitis, despite changes in hormones that are known to increase with obesity and influence inflammation. In fact, researchers found calorie-restricted mice had a higher mortality rate in response to infection with H. hepaticus, dying before tumors even developed.

"Future studies should examine the association between body fat percentage and immune responses to infections leading to inflammatory bowel diseases," Fenton said. "Understanding how a low-calorie diet increases mortality in this model may lead to new treatments for the disease in humans."


Story Source:

The above story is based on materials provided by Michigan State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sarah J. McCaskey, Elizabeth A. Rondini, Jenifer I. Fenton. Differential effects of energy balance on experimentally-induced colitis. World Journal of Gastroenterology, 2012; 18 (7): 627 DOI: 10.3748/wjg.v18.i7.627

Cite This Page:

Michigan State University. "Low-calorie diet may be harmful for bowel disease patients." ScienceDaily. ScienceDaily, 20 March 2012. <www.sciencedaily.com/releases/2012/03/120320152003.htm>.
Michigan State University. (2012, March 20). Low-calorie diet may be harmful for bowel disease patients. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2012/03/120320152003.htm
Michigan State University. "Low-calorie diet may be harmful for bowel disease patients." ScienceDaily. www.sciencedaily.com/releases/2012/03/120320152003.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins