Featured Research

from universities, journals, and other organizations

Arteries under pressure early on: Mice fed a high-fat diet show signs of artery damage after only six weeks

Date:
April 3, 2012
Source:
Springer
Summary:
High fat diets cause damage to blood vessels earlier than previously thought, and these structural and mechanical changes may be the first step in the development of high blood pressure.

High fat diets cause damage to blood vessels earlier than previously thought, and these structural and mechanical changes may be the first step in the development of high blood pressure. These findings in mice, by Marie Billaud and colleagues from the University of Virginia School of Medicine in the US, are published online in Springer's Journal of Cardiovascular Translational Research.

Related Articles


With age, increasing weight and metabolic disease, the internal walls of our large arteries progressively thicken and become less elastic, which can lead to furring up of the arteries (atherosclerosis) and increased resistance and high blood pressure in severe cases. At present, researchers and physicians tend to measure arterial compliance (a measure of arterial stiffness) in large arteries in relatively advanced stages of metabolic diseases.

However, this may not provide the full picture of when a disease starts and how it develops. In addition, previous work has suggested that structural alterations in the walls of small arteries are the most potent predictor of cardiovascular diseases, suggesting that early identification of these changes is important.

Billaud and team compared the arterial compliance of two different sized arteries: carotid (large) and thoracodorsal (smaller) in two groups of mice: one fed a high-fat diet for six weeks; the other a control group on a traditional diet.

They found that the structural and mechanical properties of small arteries were rapidly altered, even after only six weeks of high fat feeding. Specifically, the compliance of the smaller arteries was dramatically reduced in the mice on the high-fat diet, whereas there was no change in stiffness in the larger arteries. The researchers also found a build-up of collagen in the walls of the smaller arteries.

The authors conclude: "These results suggest that, at an early stage of obesity, the structural properties of small and large arteries are altered whereas arterial stiffness is only observed in small vessels. This implies that small vessels are targeted earlier compared to large arteries, and this could therefore play a role in the development of hypertension associated with a long-term caloric-enriched diet.


Story Source:

The above story is based on materials provided by Springer. Note: Materials may be edited for content and length.


Journal Reference:

  1. Marie Billaud, Scott R. Johnstone, Brant E. Isakson. Loss of Compliance in Small Arteries, but Not in Conduit Arteries, After 6Weeks Exposure to High Fat Diet. Journal of Cardiovascular Translational Research, 2012; DOI: 10.1007/s12265-012-9354-y

Cite This Page:

Springer. "Arteries under pressure early on: Mice fed a high-fat diet show signs of artery damage after only six weeks." ScienceDaily. ScienceDaily, 3 April 2012. <www.sciencedaily.com/releases/2012/04/120403112004.htm>.
Springer. (2012, April 3). Arteries under pressure early on: Mice fed a high-fat diet show signs of artery damage after only six weeks. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2012/04/120403112004.htm
Springer. "Arteries under pressure early on: Mice fed a high-fat diet show signs of artery damage after only six weeks." ScienceDaily. www.sciencedaily.com/releases/2012/04/120403112004.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins