Featured Research

from universities, journals, and other organizations

Immune cells, 'macrophages' become activated by body temperature

Date:
April 9, 2012
Source:
National Institute for Physiological Sciences
Summary:
Scientists have identified the mechanism through which TRPM2 is activated by body temperature with hydrogen peroxide produced by immune reactions.

Macrophages playing an important role in the immune system eat and fight against pathogens and foreign substances in the very beginning of infection. In this condition, macrophages produce reactive oxygen species for sterilization. However, the relation with the temperature sensor was not previously known.

Professor Makoto Tominaga from National Institute for Physiological Sciences (Okazaki Institute for Integrative Bioscience), National Institutes of Natural Sciences, and his research team member Ms. Makiko Kashio have identified the mechanism through which TRPM2 is activated by body temperature with hydrogen peroxide (a kind of reactive oxygen species) produced by immune reactions.

This research result was reported (online in the week of 9th April, 2012) by Proceedings of the National Academy of Sciences.

The research group focused on the relation between hydrogen peroxide and TRPM2. Although TRPM2 is usually activated by high temperature near 48oC in the absence of endogenous ligands, it becomes activated at our normal body temperature with hydrogen peroxide production. It means that hydrogen peroxide works as "a switch" which controls TRPM2 function. In addition, they found that phagocytic activity of macrophages was enhanced in the febrile temperature (38.5℃).

Professor Tominaga says, “It was also revealed that oxidation of TRPM2 by hydrogen peroxide is involved in the switch-on mechanism and we identified a single amino acid which is oxidized. This newly identified mechanism of TRPM2 regulation may lead to the development of new treatment strategies or drugs for infection. When we are infected with bacteria, we often run a fever, and it is known that body temperature might be important for our immune system. TRPM2 might explain the mechanism through which fever boosts up our immune system. ”

This result was supported by Grant-in-Aid for Scientific Research from the MEXT, Japan.


Story Source:

The above story is based on materials provided by National Institute for Physiological Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Makiko Kashio, Takaaki Sokabe, Kenji Shintaku, Takayuki Uematsu, Naomi Fukuta, Noritada Kobayashi, Yasuo Mori, and Makoto Tominaga. Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions. Proceedings of the National Academy of Sciences., April 9, 2012 DOI: 10.1073/pnas.1114193109

Cite This Page:

National Institute for Physiological Sciences. "Immune cells, 'macrophages' become activated by body temperature." ScienceDaily. ScienceDaily, 9 April 2012. <www.sciencedaily.com/releases/2012/04/120409164515.htm>.
National Institute for Physiological Sciences. (2012, April 9). Immune cells, 'macrophages' become activated by body temperature. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2012/04/120409164515.htm
National Institute for Physiological Sciences. "Immune cells, 'macrophages' become activated by body temperature." ScienceDaily. www.sciencedaily.com/releases/2012/04/120409164515.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins