Featured Research

from universities, journals, and other organizations

Depression linked with increased risk of peripheral artery disease

Date:
August 9, 2012
Source:
University of California - San Francisco
Summary:
Depression was linked with an increased risk of peripheral artery disease in a study of more than one thousand men and women with heart disease conducted by researchers at the San Francisco VA Medical Center and the University of California, San Francisco.

Depression was linked with an increased risk of peripheral artery disease (PAD) in a study of more than 1,000 men and women with heart disease conducted by researchers at the San Francisco VA Medical Center and the University of California, San Francisco.

Related Articles


PAD is a circulatory problem in which narrowed arteries reduce blood flow to the limbs -- usually the legs and feet -- resulting in pain, reduced mobility and, in extreme cases, gangrene and amputation.

The study was published electronically on July 26 in the Journal of the American Heart Association.

Marlene Grenon, MD, CM, a vascular surgeon at SFVAMC and an assistant professor of Surgery at UCSF, led the analysis of data from 1,024 participants in the Heart and Soul Study, a prospective study of men and women with coronary artery disease who were followed for an average of approximately seven years.

"We discovered that there was an association between depression and PAD at baseline, and also found that the patients who were depressed at the beginning of the study had a higher likelihood of developing PAD during follow-up at seven years," said Grenon.

"These findings add to the growing body of research showing the importance of depression in both the development and progression of PAD," said senior author Beth Cohen, MD, MAS, a physician at SFVAMC and an assistant professor of medicine at UCSF. "This also emphasizes the need for medical providers to be attentive to the mental health of their patients who have developed, or who are at risk for, PAD."

The authors found that some of the risk for PAD was partly explained by modifiable risk factors such as smoking and reduced physical activity.

"We still don't know which comes first," said Grenon. "Is it that patients with PAD become depressed because their mobility is impaired, or that people who are depressed engage in unhealthy behaviors such as smoking and lack of exercise, and are thus more at risk of developing PAD? Or might it be a vicious cycle, where one leads to the other?"

Further research is needed to tease out cause and effect, she said.

The study authors suggest that whatever the initial cause, lifestyle modifications such as being more physically active, eating better, quitting smoking and managing stress more effectively might reduce the risk for the association, as well as potentially address symptoms of both PAD and depression.

"These lifestyle changes would be considered healthy for anyone, and would also help overall cardiovascular health," said Grenon.

"As providers, we can help patients recognize the connections between mental and physical health," added Cohen. "This may help reduce the stigma of mental health diagnosis and encourage patients to seek treatment for problems such as depression."

Co-authors of the study are Jade Hiramoto, MD, of UCSF; Kim J. Smolderen, PhD, of Saint Luke's Mid America Heart Institute, Kansas City, MO and Tilburg University, Netherlands; Eric Vittinghof, PhD, of UCSF; and Mary A. Whooley, MD, of SFVAMC and UCSF and Principal Investigator of the Heart and Soul Study.


Story Source:

The above story is based on materials provided by University of California - San Francisco. The original article was written by Jennifer O'Brien. Note: Materials may be edited for content and length.


Journal Reference:

  1. S Marlene Grenon, Jade Hiramoto, Kim G. Smolderen, Eric Vittinghoff, Mary A. Whooley, and Beth E. Cohen. Association Between Depression and Peripheral Artery Disease: Insights From the Heart and Soul Study. J Am Heart Assoc., July 25, 2012 DOI: 10.1161/%u200BJAHA.112.002667

Cite This Page:

University of California - San Francisco. "Depression linked with increased risk of peripheral artery disease." ScienceDaily. ScienceDaily, 9 August 2012. <www.sciencedaily.com/releases/2012/08/120809100250.htm>.
University of California - San Francisco. (2012, August 9). Depression linked with increased risk of peripheral artery disease. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2012/08/120809100250.htm
University of California - San Francisco. "Depression linked with increased risk of peripheral artery disease." ScienceDaily. www.sciencedaily.com/releases/2012/08/120809100250.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins