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Shared pathway links Lou Gehrig's disease with spinal muscular atrophy

Date:
September 27, 2012
Source:
Harvard Medical School
Summary:
Scientists have long known the main proteins that lead to the development of amyotrophic lateral sclerosis and spinal muscular atrophy, respectively. Now research shows that these two motor neuron diseases likely share a pathway that leads to the development of disease.

These are fibroblasts from an unaffected individual (left) and an ALS patient with a FUS mutation. The cell nucleus is shown in blue and the "gems" are the green dots within the nuclei. The nuclei in the white boxes are magnified. Image courtesy of Reed laboratory.
Credit: Image courtesy of Harvard Medical School

Researchers of motor neuron diseases have long had a hunch that two fatal diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), might somehow be linked. A new study confirms that this link exists.

"Our study is the first to link the two diseases on a molecular level in human cells," said Robin Reed, Harvard Medical School professor of cell biology and lead investigator of the study.

The results will be published online in the September 27 issue of Cell Reports. ALS, or Lou Gehrig's disease, which has an adult onset, affects neurons that control voluntary muscles. As a result, muscles start to weaken, and patients eventually lose the ability to move their arms, legs and other parts of the body. In contrast, patients who have SMA tend to be infants and young children. Symptoms are similar to ALS, with lack of ability to control muscles being the major symptom. In both diseases, the most common cause of death is the loss of muscle function in the chest, resulting in respiratory failure.

Previous studies have shown that one of the causes of ALS is mutation of the FUS gene, and that a deficiency in the survival of motor neuron (SMN) protein causes SMA disease. The SMN protein is present in bodies in the nucleus known as Gemini of Coiled Bodies, or gems. Reed's lab connected the FUS protein to the SMN protein and the formation of gems in cellular nuclei.

"Nobody really knows what the function of gems are," said Reed. "The consensus so far is that they might be involved in biogenesis of crucial nuclear RNAs."

The researchers arrived at this pathway by studying human fibroblasts, cells that form the basis of connective tissue. "Unlike other studies of ALS and SMA, in which post-mortem tissue is normally used, we used fibroblasts from patients. These cells are easily accessible because they can be obtained from patients' skin and may provide a better idea of what happens in the human body," said Reed.

Reed and colleagues began the study by showing that the FUS protein is essential for normal gem levels. Without it, gem levels in ALS fibroblasts are much lower than in control fibroblasts.

This feature of ALS fibroblasts led the team to connect the disease with SMA. Previous studies had shown that when cells were deficient in SMN protein, fibroblasts also lacked gems in the nuclei. The loss of gems as a final result in both the SMA and ALS pathways led Reed and her team to believe that they might, in fact, be part of one larger pathway.

"The question now is whether the loss of gems is a cause of the disease or a marker for the disease," said Reed.

Reed is hopeful that even if the loss of gems is a marker, it could be used as a diagnostic tool to determine if someone who is presenting symptoms has ALS. "We will need to find out if the loss of gems is applicable to all cases of ALS or if it is specific to ALS patients with mutations in the FUS gene," added Reed.

Either way, Reed describes these finds as killing two birds with one stone. "This common pathway may mean common treatment and resources."


Story Source:

The above story is based on materials provided by Harvard Medical School. The original article was written by Shraddha Chakradhar. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tomohiro Yamazaki, Shi Chen, Yong Yu, Biao Yan, TylerC. Haertlein, MonicaA. Carrasco, JuanC. Tapia, Bo Zhai, Rita Das, Melanie Lalancette-Hebert, Aarti Sharma, Siddharthan Chandran, Gareth Sullivan, AgnesLumi Nishimura, ChristopherE. Shaw, SteveP. Gygi, NeilA. Shneider, Tom Maniatis, Robin Reed. FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA. Cell Reports, 2012; DOI: 10.1016/j.celrep.2012.08.025

Cite This Page:

Harvard Medical School. "Shared pathway links Lou Gehrig's disease with spinal muscular atrophy." ScienceDaily. ScienceDaily, 27 September 2012. <www.sciencedaily.com/releases/2012/09/120927124156.htm>.
Harvard Medical School. (2012, September 27). Shared pathway links Lou Gehrig's disease with spinal muscular atrophy. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2012/09/120927124156.htm
Harvard Medical School. "Shared pathway links Lou Gehrig's disease with spinal muscular atrophy." ScienceDaily. www.sciencedaily.com/releases/2012/09/120927124156.htm (accessed September 2, 2014).

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