Featured Research

from universities, journals, and other organizations

Vitamin D could hold vital key to arresting development of Alzheimer’s disease

Date:
November 8, 2012
Source:
Kingston University
Summary:
Scientists have uncovered evidence that lack of a particular form of vitamin D is associated with Alzheimer's disease.

Scientists at London's Kingston University have uncovered evidence that lack of a particular form of vitamin D is associated with Alzheimer's disease.

Working in collaboration with researchers from Brighton and Sussex Medical School and the Sussex Partnership NHS Foundation, the Kingston researchers spent six months analysing blood samples from patients with Alzheimer's. They compared test results from those not being treated with any drugs to those from people on medication and a further group who did not have the condition.

Lead researcher Professor Declan Naughton, from Kingston University's School of Life Sciences, said the results had revealed some important facts. Alzheimer's patients who were not using medication had very poor stores of vitamin D2. "The vitamin was either non-existent or in such low quantities that it could barely be measured," he explained. "In comparison, people in the study who were either being treated with drugs to control their Alzheimer's or who didn't have the condition at all showed far higher levels."

In a further twist, the scientists found indications that Acetylcholinesterase inhibitors -- used to treat the early stages of Alzheimer's -- might play a role in actually "switching on" the body's absorption of vitamin D2.

"There are several different types of vitamin D that can be active in the body," Professor Naughton explained. "The key point in this study was that a blood test, which we developed at Kingston University, was for the first time able to accurately measure which, if any, of the different variations of vitamin D were present in Alzheimer's patients."

There had been speculation in the scientific community in the past that vitamin D, or a lack of it, might have a role to play in the development of Alzheimer's. However, this was believed to be the first time scientists had pinpointed the connection with the vitamin D2 metabolite, Professor Naughton said.

Although more research was still needed, the findings could eventually pave the way for medical intervention to restore levels of that particular strand of vitamin D, he added. Such an approach had the potential to have a marked impact on the devastating condition, which currently affects almost half a million people in the United Kingdom alone. "Further investigations are now needed to determine whether simple dietary advice or giving a specific supplement could restore beneficial levels in Alzheimer's patients," Professor Naughton said.

Vitamin D plays a key role in the development of healthy bodies. It helps to form and maintain strong teeth and bones and is thought to protect against a number of diseases such as cancers, cardiovascular conditions and neurological problems. "Most people associate vitamin D with exposure to the sun. The idea that a lack of the storage form originating from foods such as oily fish and egg yolks might be implicated in the development and progression of Alzheimer's definitely merits further research," Professor Naughton said.


Story Source:

The above story is based on materials provided by Kingston University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Iltaf Shah, Andrea Petroczi, Naji Tabet, Anthony Klugman, Mokhtar Isaac, Declan P. Naughton. Low 25OH Vitamin D2 Levels Found in Untreated Alzheimer’s Patients, Compared to Acetylcholinesterase-Inhibitor Treated and Controls. Current Alzheimer Research, 2012; 9 (9): 1069-1076 [link]

Cite This Page:

Kingston University. "Vitamin D could hold vital key to arresting development of Alzheimer’s disease." ScienceDaily. ScienceDaily, 8 November 2012. <www.sciencedaily.com/releases/2012/11/121108131452.htm>.
Kingston University. (2012, November 8). Vitamin D could hold vital key to arresting development of Alzheimer’s disease. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2012/11/121108131452.htm
Kingston University. "Vitamin D could hold vital key to arresting development of Alzheimer’s disease." ScienceDaily. www.sciencedaily.com/releases/2012/11/121108131452.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins