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Is the detection of early markers of Epstein Barr virus of diagnostic value?

Date:
November 16, 2012
Source:
Mary Ann Liebert, Inc./Genetic Engineering News
Summary:
Epstein-Barr virus (EBV) is the cause of infectious mononucleosis and a risk for serious disease in liver transplant recipients. Molecular tests that can identify early protein markers produced by EBV may have value for diagnosing active infection.

Epstein-Barr virus (EBV) is the cause of infectious mononucleosis and a risk for serious disease in liver transplant recipients. Molecular tests that can identify early protein markers produced by EBV may have value for diagnosing active infection. The benefits of this diagnostic approach in patients with mononucleosis and in EBV-infected transplant patients are evaluated in an article published in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers.

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Andrea Crowley, Jeff Connell, Kirsten Schaffer, William Halla, and Jaythoon Hassan, University College Dublin and St. Vincent's University Hospital, Dublin, Ireland, compared three immunoassay methods for detecting antibodies produced by the body in response to EBV infection and the presence of proteins that comprise the EBV early antigen complex. The researchers determined which of the diagnostic tests could better predict EBV infection in patients with mononucleosis or in immunosuppressed adult liver transplant recipients.

"Having the ability to predict the risk of developing EBV-induced lymphoproliferative disorders after a transplant has important consequences for patient care, as it would allow for prompt therapy and could potentially decrease patient mortality," says Editor-in-Chief Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland.


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc./Genetic Engineering News. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andrea Crowley, Jeff Connell, Kirsten Schaffer, William Hall, and Jaythoon Hassan. Is There Diagnostic Value in Detection of Immunoglobulin G Antibodies to the Epstein–Barr Virus Early Antigen? BioResearch, 2012 DOI: 10.1089/biores.2012.0274

Cite This Page:

Mary Ann Liebert, Inc./Genetic Engineering News. "Is the detection of early markers of Epstein Barr virus of diagnostic value?." ScienceDaily. ScienceDaily, 16 November 2012. <www.sciencedaily.com/releases/2012/11/121116161105.htm>.
Mary Ann Liebert, Inc./Genetic Engineering News. (2012, November 16). Is the detection of early markers of Epstein Barr virus of diagnostic value?. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2012/11/121116161105.htm
Mary Ann Liebert, Inc./Genetic Engineering News. "Is the detection of early markers of Epstein Barr virus of diagnostic value?." ScienceDaily. www.sciencedaily.com/releases/2012/11/121116161105.htm (accessed October 30, 2014).

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