Featured Research

from universities, journals, and other organizations

New electrically conductive polymer nanoparticles can generate heat to kill colorectal cancer cells

Date:
November 20, 2012
Source:
Wake Forest Baptist Medical Center
Summary:
Researchers have modified electrically conductive polymers, commonly used in solar energy applications, to develop revolutionary polymer nanoparticles for a medical application. When the nanoparticles are exposed to infrared light, they generate heat that can be used to kill colorectal cancer cells.

Researchers at Wake Forest Baptist Medical Center have modified electrically conductive polymers, commonly used in solar energy applications, to develop revolutionary polymer nanoparticles (PNs) for a medical application. When the nanoparticles are exposed to infrared light, they generate heat that can be used to kill colorectal cancer cells.

The study was directed by Assistant Professor of Plastic and Reconstructive Surgery, Nicole H. Levi-Polyachenko, Ph.D., and done in collaboration with colleagues at the Center for Nanotechnology and Molecular Materials at Wake Forest University. This study was recently published online, ahead of print, in the journal, Macromolecular Bioscience.

Levi-Polyachenko and her team discovered a novel formulation that gives the polymers two important capabilities for medical applications: the polymers can be made into nanoparticles that are easily dispersed in water and generate a lot of heat when exposed to infrared light.

Results of this study showed that when colorectal cancer cells incubated with the PNs were exposed to five minutes of infrared light, the treatment killed up to 95 percent of cells. "The results of this study demonstrate how new medical advancements are being developed from materials science research," said Levi-Polyachenko.

The team made polymer nanoparticles and showed that they could undergo repeated cycles of heating and cooling without affecting their heating ability. This offers advantages over metal nanoparticles, which can melt during photothermal treatments, leading to a loss of heating efficiency. This also allows for subsequent treatments to target cells that are resistant to heat-induced killing.

A challenge with other electrically-conductive polymers that have recently been explored for photothermal therapy is that these other polymers absorb across a wide range of infrared light. Christopher M. MacNeill, Ph.D., post-doctoral researcher at Wake Forest and first author on the paper, noted that, "we have specifically used electrically-conductive polymers designed to absorb a very narrow region of infrared light, and have also developed small, 50-65nm, polymer nanoparticles in order to optimize both biological transport as well as heat transfer." For example, 50nm is about 2000 times smaller than a human hair.

In addition, the new PNs are organic and did not show any evidence of toxicity, alleviating concerns about the effect of nanoparticles that may potentially linger in the body.

"There is a lot more research that needs to be done so that these new nanoparticles can be used safely in patients," Levi-Polyachenko cautioned, "but the field of electrically-conductive polymers is broad and offers many opportunities to develop safe, organic nanoparticles for generating heat locally in a tissue. We are very enthusiastic about future medical applications using these new nanoparticles, including an alternative approach for treating colorectal cancer."

The study was funded by the Department of Plastic and Reconstructive Surgery at Wake Forest Baptist Medical Center.


Story Source:

The above story is based on materials provided by Wake Forest Baptist Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christopher M. MacNeill, Robert C. Coffin, David L. Carroll, Nicole H. Levi-Polyachenko. Low Band Gap Donor-Acceptor Conjugated Polymer Nanoparticles and their NIR-mediated Thermal Ablation of Cancer Cells. Macromolecular Bioscience, 2012; DOI: 10.1002/mabi.201200241

Cite This Page:

Wake Forest Baptist Medical Center. "New electrically conductive polymer nanoparticles can generate heat to kill colorectal cancer cells." ScienceDaily. ScienceDaily, 20 November 2012. <www.sciencedaily.com/releases/2012/11/121120152413.htm>.
Wake Forest Baptist Medical Center. (2012, November 20). New electrically conductive polymer nanoparticles can generate heat to kill colorectal cancer cells. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2012/11/121120152413.htm
Wake Forest Baptist Medical Center. "New electrically conductive polymer nanoparticles can generate heat to kill colorectal cancer cells." ScienceDaily. www.sciencedaily.com/releases/2012/11/121120152413.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins