Featured Research

from universities, journals, and other organizations

Research reveals new drug target urgently needed for tuberculosis therapy

Date:
December 20, 2012
Source:
Public Library of Science
Summary:
One third of the world is infected with the bacterium that causes tuberculosis, a disease that is increasingly difficult to treat because of wide spread resistance to available drugs. Researchers have identified a fresh target to develop new drugs for TB. The study shows why the target will be important in developing new TB treatments.

One third of the world is infected with the bacterium that causes tuberculosis (TB), a disease that is increasingly difficult to treat because of wide spread resistance to available drugs. Researchers from the Institute of Pharmacology and Structural Biology (CNRS, Universitι de Toulouse) in Toulouse (France) have identified a fresh target to develop new drugs for TB. The study, published in the Open Access journal PLOS Pathogens, shows why the target will be important in developing new TB treatments.

The deadliest form of human tuberculosis is caused by Mycobacterium tuberculosis (M.tb). The burden of infection continues to increase and every year the world sees 8 million new cases and nearly 2 million deaths. TB, which occurs mostly in developing countries (including China, India and Brazil), drastically hinders economic growth. Current tuberculosis treatments are nearly 50 years old, take more than six months to complete and have many side effects, which makes it difficult for people to take the full course of drugs. The treatments have also become less effective because new bacterial strains are resistant to multiple drugs. There is an urgent need to find drugs with new modes of action that will shorten the duration of treatment, improve ways to fight drug-resistant tuberculosis and treat dormant infections to prevent them from later developing into full blown disease.

The cell envelope of M.tb has an unusually high content of substances called lipids which have unusual composition and are known to play an important role in the causing disease. The production of these disease causing lipids was known to be controlled by the action of a protein which is the enzyme PptT in M.tb.

In this study, the researchers found that production of PptT is needed for growth of M.tb in a culture dish. It is also needed for growth and survival of M.tb in a mouse, which serves as a model for human disease. These findings are the reasons why PptT should be a very good drug target and allow the development of new drugs against TB. The study has also developed a way to quickly test hundreds of thousands of chemical agents (aka drugs) that block the action of Ppt and growth of M.tb. This approach is important and has been used by drug companies to develop drugs to many human diseases.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Leblanc C, Prudhomme T, Tabouret G, Ray A, Burbaud S, et al. 4'-Phosphopantetheinyl Transferase PptT, a New Drug Target Required for Mycobacterium tuberculosis Growth and Persistence In Vivo. PLOS Pathogens, 2012; 8 (12): e1003097 DOI: 10.1371/journal.ppat.1003097

Cite This Page:

Public Library of Science. "Research reveals new drug target urgently needed for tuberculosis therapy." ScienceDaily. ScienceDaily, 20 December 2012. <www.sciencedaily.com/releases/2012/12/121220171806.htm>.
Public Library of Science. (2012, December 20). Research reveals new drug target urgently needed for tuberculosis therapy. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2012/12/121220171806.htm
Public Library of Science. "Research reveals new drug target urgently needed for tuberculosis therapy." ScienceDaily. www.sciencedaily.com/releases/2012/12/121220171806.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) — A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) — The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins