Featured Research

from universities, journals, and other organizations

New method of predicting response to chemotherapy in bowel cancer

Date:
January 18, 2013
Source:
Royal College of Surgeons in Ireland (RCSI)
Summary:
Scientists have developed a new method of predicting which patients with bowel (colorectal) cancer will respond effectively to chemotherapy.

Scientists at the Royal College of Surgeons in Ireland (RCSI) and Beaumont Hospital have developed a new method of predicting which patients with bowel (colorectal) cancer will respond effectively to chemotherapy.

Related Articles


The results of this study are published in the current issue of the journal Cancer Research.

The discovery could, in the future, help identify individuals who will not respond to chemotherapy, before they commence treatment, and may therefore require additional therapies. The new tool measures the amount of drug required for a cancer cell to die without harming healthy tissue. This prediction tool may also be used in clinical trails to develop new drugs to treat bowel cancer.

Commenting on the results, lead researcher, Professor Jochen Prehn, Director of the Centre for Systems Medicine at RCSI said: "Our study has enabled us to predict which patients are likely to be resistant to chemotherapy by examining how certain proteins in their cancer cells interact. We hope that the clinical decision-making tool that we have designed will enable doctors to develop personalised therapies for patients to ensure the best outcomes and potentially avoiding unnecessary chemotherapy and the negative side effects that go with it."

Chemotherapy destroys cancer cells by bringing on a process of programmed cell death, known as apoptosis. However, sometimes mutations in cancer cells alter the levels of certain proteins and prevent this process of cell death occurring which results in chemotherapy being ineffective in some individuals with bowel cancer. In other patients, mutations in cancer cells have the opposite effect and promote the destruction of the cancer cells.

"The prediction tool also has the potential to be used in clinical trials so that new drugs can be developed for bowel cancer patients who are resistant to chemotherapy. The model we developed in this study could eventually be applied in other cancers." Professor Prehn concluded.

The first author on the study is Andreas Linder, a PhD researcher who carried out the research with Professor Prehn and RCSI colleagues (Dr. Caoimhin Concannon, Dr. Gerhardt Boukes, Dr. Suzanne Hector, Dr. Heinrich Huber) in collaboration with clinicians (Deborah Ryan, Mary Cannon, Karen Boland, Ms. Deborah McNamara, Professor Elaine Kay, Prof Frank Murray) and research nurse Joan Kehoe at Beaumont Hospital, Dublin, and collaborators at St. Jude's Children's Research Hospital, Memphis, Tennessee (Dr Fabien Llambi and Professor Douglas Green).

Bowel cancer is the second most common cancer in Ireland. In 2009, 2,271 people were diagnosed with the disease. It is also the second most common cause of cancer death in Ireland. (1)

The research was funded by grants from the Health Research Board, Science Foundation Ireland, European Union FP7 and a Higher Education Authority PRTLI Cycle 4- Clinician Scientist Fellowship Award.

(1) Source: Irish Cancer Society


Story Source:

The above story is based on materials provided by Royal College of Surgeons in Ireland (RCSI). Note: Materials may be edited for content and length.


Cite This Page:

Royal College of Surgeons in Ireland (RCSI). "New method of predicting response to chemotherapy in bowel cancer." ScienceDaily. ScienceDaily, 18 January 2013. <www.sciencedaily.com/releases/2013/01/130118111552.htm>.
Royal College of Surgeons in Ireland (RCSI). (2013, January 18). New method of predicting response to chemotherapy in bowel cancer. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2013/01/130118111552.htm
Royal College of Surgeons in Ireland (RCSI). "New method of predicting response to chemotherapy in bowel cancer." ScienceDaily. www.sciencedaily.com/releases/2013/01/130118111552.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins