Featured Research

from universities, journals, and other organizations

Beta-catenin molecule is required for tooth root formation

Date:
January 23, 2013
Source:
International & American Associations for Dental Research
Summary:
The tooth root, together with the surrounding periodontium, maintains the tooth in the jaw. The root develops after the crown forms, a process called morphogenesis. While the molecular and cellular mechanisms of early tooth development and crown morphogenesis have been extensively studied, little is known about the molecular mechanisms controlling tooth root formation.

The International and American Associations for Dental Research (IADR/AADR) recently published a paper titled "-catenin is Required in Odontoblasts for Tooth Root Formation." The paper, written by lead authors Tak-Heun Kim and Cheol-Hyeon Bae, Chonbuk National University Korea School of Dentistry, Laboratory for Craniofacial Biology, is published in the IADR/AADR Journal of Dental Research.

The tooth root, together with the surrounding periodontium, maintains the tooth in the jaw. The root develops after the crown forms, a process called morphogenesis. While the molecular and cellular mechanisms of early tooth development and crown morphogenesis have been extensively studied, little is known about the molecular mechanisms controlling tooth root formation.

In this study, Kim and Bae et al show that a protein called -catenin is strongly expressed in odontoblasts -- the cells that develop the tooth dentin, and is required for root formation. Tissue-specific inactivation of -catenin in developing odontoblasts produced molars lacking roots and aberrantly thin incisors.

At the beginning of root formation in the mutant molars, the cervical loop epithelium extended apically to form Hertwig's epithelial root sheath (HERS), but root odontoblast differentiation was disrupted and followed by the loss of a subset of HERS inner layer cells. However, outer layer of HERS extended without the root, and the mutant molars finally erupted. The periodontal tissues invaded extensively into the dental pulp. These results indicate that there is a cell-autonomous requirement for Wnt/-catenin signaling in the dental mesenchyme for root formation.

"The striking tooth phenotypes in this study shed light on how Wnt signaling regulates odontoblast fate and root development," said JDR Associate Editor Joy Richman.


Story Source:

The above story is based on materials provided by International & American Associations for Dental Research. Note: Materials may be edited for content and length.


Journal References:

  1. X.-P. Wang. Tooth Eruption without Roots. J DENT RES, January 23, 2013 DOI: 10.1177/0022034512474469
  2. T.H. Kim, C.H. Bae, J.C. Lee, S.O. Ko, X. Yang, R. Jiang, and E.S. Cho. β-catenin is Required in Odontoblasts for Tooth Root Formation. J DENT RES, January 23, 2013 DOI: 10.1177/0022034512470137

Cite This Page:

International & American Associations for Dental Research. "Beta-catenin molecule is required for tooth root formation." ScienceDaily. ScienceDaily, 23 January 2013. <www.sciencedaily.com/releases/2013/01/130123144228.htm>.
International & American Associations for Dental Research. (2013, January 23). Beta-catenin molecule is required for tooth root formation. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2013/01/130123144228.htm
International & American Associations for Dental Research. "Beta-catenin molecule is required for tooth root formation." ScienceDaily. www.sciencedaily.com/releases/2013/01/130123144228.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins