Featured Research

from universities, journals, and other organizations

Breastfeeding OK for mothers taking immunosuppressant drug, study suggests

Date:
January 24, 2013
Source:
American Society of Nephrology (ASN)
Summary:
Women taking the immunosuppressant tacrolimus can rest assured that breast feeding will not elevate their babies' exposure to the drug, according to a new study. The findings are good news for young women who have received an organ transplant in the past or who are taking the drug for other reasons.

Women taking the immunosuppressant tacrolimus can rest assured that breast feeding will not elevate their babies' exposure to the drug, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The findings are good news for young women who have received an organ transplant in the past or who are taking the drug for other reasons.

Related Articles


Women taking the tacrolimus have previously been advised not to breast feed due to the possibility that the drug might be transferred to the baby, which could potentially suppress the baby's developing immune system. While there are many benefits to breast-feeding, there is very little known about the safety of breast-feeding while taking tacrolimus.

Kate Bramham, MRCP (King's College London) and her colleagues looked to determine the extent to which tacrolimus is transferred to infants via breast milk. Fourteen women taking tacrolimus during pregnancy and lactation, and their 15 infants (11 of whom were exclusively breast-fed) were assessed.

Among the major findings:

• Babies born to mothers taking tacrolimus had high levels of the drug in their blood at birth, likely due to transfer across the placenta, but the levels fell as the liver cleared the drug.

• Both babies who were breast-fed and those who were bottle-fed cleared the drug at the same rate. Most cleared the drug by two weeks.

• The breast milk of mothers taking tacrolimus contained only very low levels of the drug. (If babies were to take the same amount of tacrolimus per kilogram of body weight as their mothers, they would need to consume approximately 150 liters of breast milk per day.)

"Our study shows that levels of the drug are not significantly increased through breast feeding. Although more studies are needed on the safety of tacrolimus, the findings would suggest that women who wish to breastfeed should not be discouraged from doing so," said Dr. Bramham. "The advantages, particularly in preterm infants, need to be weighed against the theoretical disadvantages of minimal ingestion through breast milk," she added. Of note, women who have received a kidney transplant in the past are more likely to have early deliveries.

Study co-authors include Gary Chusney, Janet Lee PhD, Liz Lightstone, PhD, FRCP, and Catherine Nelson-Piercy, FRCP, FRCOG.


Story Source:

The above story is based on materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Journal Reference:

  1. K. Bramham, G. Chusney, J. Lee, L. Lightstone, C. Nelson-Piercy. Breastfeeding and Tacrolimus: Serial Monitoring in Breast-Fed and Bottle-Fed Infants. Clinical Journal of the American Society of Nephrology, 2013; DOI: 10.2215/CJN.06400612

Cite This Page:

American Society of Nephrology (ASN). "Breastfeeding OK for mothers taking immunosuppressant drug, study suggests." ScienceDaily. ScienceDaily, 24 January 2013. <www.sciencedaily.com/releases/2013/01/130124183437.htm>.
American Society of Nephrology (ASN). (2013, January 24). Breastfeeding OK for mothers taking immunosuppressant drug, study suggests. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2013/01/130124183437.htm
American Society of Nephrology (ASN). "Breastfeeding OK for mothers taking immunosuppressant drug, study suggests." ScienceDaily. www.sciencedaily.com/releases/2013/01/130124183437.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins