Featured Research

from universities, journals, and other organizations

Treatment to prevent Alzheimer's disease moves a step closer

Date:
February 1, 2013
Source:
Lancaster University
Summary:
A new drug to prevent the early stages of Alzheimer’s disease could enter clinical trials in a few years’ time, according to scientists.

A new drug to prevent the early stages of Alzheimer's disease could enter clinical trials in a few years' time according to scientists.
Credit: © Chariclo / Fotolia

A new drug to prevent the early stages of Alzheimer's disease could enter clinical trials in a few years' time according to scientists.

Alzheimer's is the most common type of dementia, which currently affects 820,000 people in the UK, with numbers expected to more than double by 2050. One in three people over 65 will die with dementia.

The disease begins when a protein called amyloid-β (Aβ) starts to clump together in senile plaques in the brain, damaging nerve cells and leading to memory loss and confusion.

Professor David Allsop and Dr Mark Taylor at Lancaster University have successfully created a new drug which can reduce the number of senile plaques by a third, as well as more than doubling the number of new nerve cells in a particular region of the brain associated with memory. It also markedly reduced the amount of brain inflammation and oxidative damage associated with the disease.

The drug was tested on transgenic mice containing two mutant human genes linked to inherited forms of Alzheimer's, so that they would develop some of the changes associated with the illness. The drug is designed to cross the blood-brain barrier and prevent the Aβ molecules from sticking together to form plaques.

Professor Allsop, who led the research and was the first scientist to isolate senile plaques from human brain, said: "When we got the test results back, we were highly encouraged. The amount of plaque in the brain had been reduced by a third and this could be improved if we gave a larger dose of the drug, because at this stage, we don't know what the optimal dose is."

The drug needs to be tested for safety before it can enter human trials, but, if it passes this hurdle, the aim would be to give the drug to people with mild symptoms of memory loss before they develop the illness.

"Many people who are mildly forgetful may go on to develop the disease because these senile plaques start forming years before any symptoms manifest themselves. The ultimate aim is to give the drug at that stage to stop any more damage to the brain, before it's too late."

The other researchers include groups led by Prof. Christian Hφlscher at Ulster University, who conducted the mouse studies, and Prof. Massimo Masserini at University of Milano-Bicocca, Italy, who measured the ability of the drug to bind to Aβ.

Support for the research was given by Alzheimer's Research UK, and the results are published in the open access journal PLOS ONE.

Dr Eric Karran, Director of Research at Alzheimer's Research UK, said: "We are pleased to have supported this study, which represents the first step to developing much-needed new treatments to fight Alzheimer's. These are promising early-stage results, and several years more work will be required to assess the potential of this approach. For science like this to make a real difference to people's lives, we must continue to invest in research."


Story Source:

The above story is based on materials provided by Lancaster University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Vadivel Parthsarathy, Paula L. McClean, Christian Hφlscher, Mark Taylor, Claire Tinker, Glynn Jones, Oleg Kolosov, Elisa Salvati, Maria Gregori, Massimo Masserini, David Allsop. A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease. PLoS ONE, 2013; 8 (1): e54769 DOI: 10.1371/journal.pone.0054769

Cite This Page:

Lancaster University. "Treatment to prevent Alzheimer's disease moves a step closer." ScienceDaily. ScienceDaily, 1 February 2013. <www.sciencedaily.com/releases/2013/02/130201100147.htm>.
Lancaster University. (2013, February 1). Treatment to prevent Alzheimer's disease moves a step closer. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/02/130201100147.htm
Lancaster University. "Treatment to prevent Alzheimer's disease moves a step closer." ScienceDaily. www.sciencedaily.com/releases/2013/02/130201100147.htm (accessed July 23, 2014).

Share This




More Mind & Brain News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Do Obese Women Have 'Food Learning Impairment'?

Do Obese Women Have 'Food Learning Impairment'?

Newsy (July 18, 2014) — Yale researchers tested 135 men and women, and it was only obese women who were deemed to have "impaired associative learning." Video provided by Newsy
Powered by NewsLook.com
Does Mixing Alcohol and Energy Drinks Boost Urge To Drink?

Does Mixing Alcohol and Energy Drinks Boost Urge To Drink?

Newsy (July 18, 2014) — A new study suggests that mixing alcohol with energy drinks makes you want to keep the party going. Video provided by Newsy
Powered by NewsLook.com
Pot Cooking Class Teaches Responsible Eating

Pot Cooking Class Teaches Responsible Eating

AP (July 18, 2014) — Following the nationwide trend of eased restrictions on marijuana use, pot edibles are growing in popularity. One Boston-area cooking class is teaching people how to eat pot responsibly. (July 18) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins