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Genetically modified tobacco plants produce antibodies to treat rabies

Date:
February 1, 2013
Source:
Federation of American Societies for Experimental Biology
Summary:
Smoking tobacco is bad for your health, but a genetically altered version of the plant might provide an inexpensive cure for the deadly rabies virus. Scientists have produced a monoclonal antibody in transgenic tobacco plants shown to neutralize the rabies virus. This antibody works by preventing the virus from attaching to nerve endings around the bite site and keeping the virus from traveling to the brain.
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Smoking tobacco might be bad for your health, but a genetically altered version of the plant might provide a relatively inexpensive cure for the deadly rabies virus. In a new research report appearing in The FASEB Journal, scientists produced a monoclonal antibody in transgenic tobacco plants that was shown to neutralize the rabies virus. This new antibody works by preventing the virus from attaching to nerve endings around the bite site and keeps the virus from traveling to the brain.

"Rabies continues to kill many thousands of people throughout the developing world every year and can also affect international travelers," said Leonard Both, M.Sc., a researcher involved in the work from the Hotung Molecular Immunology Unit at St. George's, University of London, in the United Kingdom. "An untreated rabies infection is nearly 100 percent fatal and is usually seen as a death sentence. Producing an inexpensive antibody in transgenic plants opens the prospect of adequate rabies prevention for low-income families in developing countries."

To make this advance, Both and colleagues "humanized" the sequences for the antibody so people could tolerate it. Then, the antibody was produced using transgenic tobacco plants as an inexpensive production platform. The antibody was purified from the plant leaves and characterized with regards to its protein and sugar composition. The antibody was also shown to be active in neutralizing a broad panel of rabies viruses, and the exact antibody docking site on the viral envelope was identified using certain chimeric rabies viruses.

"Although treatable by antibodies if caught in time, rabies is bad news," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This is especially true for people in the developing world where manufacturing costs lead to treatment shortages. Being able to grow safe, humanized antibodies in genetically modified tobacco should reduce costs to make treatments more accessible, and save more lives."


Story Source:

The above post is reprinted from materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. Both, C. van Dolleweerd, E. Wright, A. C. Banyard, B. Bulmer-Thomas, D. Selden, F. Altmann, A. R. Fooks, J. K.- C. Ma. Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans. The FASEB Journal, 2013; DOI: 10.1096/fj.12-219964

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Federation of American Societies for Experimental Biology. "Genetically modified tobacco plants produce antibodies to treat rabies." ScienceDaily. ScienceDaily, 1 February 2013. <www.sciencedaily.com/releases/2013/02/130201100244.htm>.
Federation of American Societies for Experimental Biology. (2013, February 1). Genetically modified tobacco plants produce antibodies to treat rabies. ScienceDaily. Retrieved July 2, 2015 from www.sciencedaily.com/releases/2013/02/130201100244.htm
Federation of American Societies for Experimental Biology. "Genetically modified tobacco plants produce antibodies to treat rabies." ScienceDaily. www.sciencedaily.com/releases/2013/02/130201100244.htm (accessed July 2, 2015).

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