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Promising target to block Staphylococcus infection discovered

Date:
February 10, 2013
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
Scientists have identified a promising lead for developing a new type of drug to treat infection caused by Staphylococcus aureus, a bacterium that frequently resists traditional antibiotics. The researchers discovered a system used by S. aureus to transport toxins that are thought to contribute to severe staph infections. These toxins -- called phenol-soluble modulins -- have gained much attention in recent years, but their multitude and diversity have hindered efforts to target them for drug development.
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FULL STORY

National Institutes of Health (NIH) scientists have identified a promising lead for developing a new type of drug to treat infection caused by Staphylococcus aureus, a bacterium that frequently resists traditional antibiotics. The researchers discovered a system used by S. aureus to transport toxins that are thought to contribute to severe staph infections. These toxins -- called phenol-soluble modulins (PSMs) -- have gained much attention in recent years, but their multitude and diversity have hindered efforts to target them for drug development.

Expanding on work that first described S. aureus PSMs in 2007, scientists at the NIH's National Institute of Allergy and Infectious Diseases found that the transport system, which they call Pmt, is common to all S. aureus PSMs and critical for bacterial proliferation and disease development in a mouse model. Their experiments suggest that a drug interfering with Pmt's function could not only prevent production of the PSM toxins, but also directly lead to bacterial death.

Although their study focused on S. aureus, the scientists suspect that Pmt performs the same role in other staphylococci, such as S. epidermidis, the leading cause of hospital-associated infections involving indwelling medical devices such as catheters, pacemakers and prosthetics. They plan to continue their studies to improve the understanding of how PSMs function and to learn how to interfere with the Pmt transport system to block disease.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Journal References:

  1. S Chatterjee et al. Essential Staphylococcus aureus toxin export system. Nature Medicine, 2013 DOI: 10.1038/nm3047
  2. Rong Wang, Kevin R Braughton, Dorothee Kretschmer, Thanh-Huy L Bach, Shu Y Queck, Min Li, Adam D Kennedy, David W Dorward, Seymour J Klebanoff, Andreas Peschel, Frank R DeLeo, Michael Otto. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nature Medicine, 2007; 13 (12): 1510 DOI: 10.1038/nm1656

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NIH/National Institute of Allergy and Infectious Diseases. "Promising target to block Staphylococcus infection discovered." ScienceDaily. ScienceDaily, 10 February 2013. <www.sciencedaily.com/releases/2013/02/130210143254.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2013, February 10). Promising target to block Staphylococcus infection discovered. ScienceDaily. Retrieved April 27, 2015 from www.sciencedaily.com/releases/2013/02/130210143254.htm
NIH/National Institute of Allergy and Infectious Diseases. "Promising target to block Staphylococcus infection discovered." ScienceDaily. www.sciencedaily.com/releases/2013/02/130210143254.htm (accessed April 27, 2015).

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