Featured Research

from universities, journals, and other organizations

Threat bias interacts with combat, gene to boost PTSD risk

Date:
February 13, 2013
Source:
NIH/National Institute of Mental Health
Summary:
Soldiers preoccupied with threat at the time of enlistment or with avoiding it just before deployment were more likely to develop post-traumatic stress disorder (PTSD), in a study of Israeli infantrymen. Such pre-deployment threat vigilance and avoidance, interacting with combat experience and an emotion-related gene, accounted for more than a third of PTSD symptoms that emerged later. Computerized training that helps modify such attention biases might help protect soldiers from the disorder.

Pine and Bar-Haim are using functional brain imaging in studies of a computer-based training method, called (ABM), that helps people learn to shift their attention away from preoccupying stimuli. For example, when performing a task that required matching angry or neutral faces to locations where they briefly flashed on a computer monitor, people with anxiety disorders typically showed faster reaction times to angry faces, signaling biased attention toward threat. In the training, their attention was repeatedly diverted to matching locations of neutral faces only. The researchers propose that offering soldiers a similar preventive intervention prior to deployment might help correct attention biases and reduce the risk of developing PTSD.
Credit: Daniel Pine, MD, NIMH Emotion and Development Branch

Soldiers preoccupied with threat at the time of enlistment or with avoiding it just before deployment were more likely to develop post-traumatic stress disorder (PTSD), in a study of Israeli infantrymen. Such pre-deployment threat vigilance and avoidance, interacting with combat experience and an emotion-related gene, accounted for more than a third of PTSD symptoms that emerged later, say National Institutes of Health scientists, who conducted the study in collaboration with American and Israeli colleagues.

"Since biased attention predicted future risk for PTSD, computerized training that helps modify such attention biases might help protect soldiers from the disorder," said Daniel Pine, M.D., of the NIH's National Institute of Mental Health (NIMH).

Pine, Yair Bar-Haim, Ph.D., of Tel Aviv University, and colleagues, report their findings, Feb. 13, 2013, in the journal JAMA Psychiatry.

Bar-Haim's team tracked 1085 male Israeli soldiers from recruitment through combat deployment during 2008-2010, to pinpoint how shifting attitudes toward threat interact with other factors to predict symptoms that develop after exposure to dangers. They expected that the more soldiers paid attention to avoiding threats just before and during deployment, the more they would suffer PTSD symptoms.

Researchers measured threat attention biases over the course of soldiers' first year of service: at the time of recruitment, about six months later -- just before deployment to combat -- and six months after deployment. Data from all three time points was collected for 487 of the soldiers.

Soldiers performed a computerized task that required paying attention to locations of neutral words, such as "data" or threatening words, such as "dead." A faster reaction time for identifying the location of threat words indicated increased threat vigilance. Slower reaction times to such word locations indicated attention away from threat, or threat avoidance.

The study also examined how threat attention bias vulnerability might be moderated by other factors, including the gene that codes for the protein on neurons that recycles the brain chemical messenger serotonin from the synapse. Versions of this serotonin transporter gene had been previously linked to PTSD risk. Evidence suggests that people with gene versions that result in less efficient recycling may be overly vigilant toward threats under normal circumstances. Yet there is also evidence that having these low-efficiency versions may help people cope with dangerous conditions, when such heightened vigilance may be adaptive.

As expected, soldiers who experienced higher combat exposure -- e.g., served in units operating outside Israel's security fence -- tended to show more threat vigilance than those with less stressful assignments. Compared to soldiers who were neither vigilant nor avoidant, soldiers with greater vigilance at recruitment or avoidance at six months -- on the eve of deployment -- had more PTSD symptoms at the end of their first year of service.

Although serotonin gene type had no direct effect on symptoms, the low efficiency gene version, combined with high threat vigilance, appeared to confer some protection to soldiers who experienced high combat exposure.

"Their natural tendency to attend to threats may lead to less adaptive emotional responses and elevated anxiety when environmental conditions are safe and stable, but to perfectly normal and adaptive responses in combat, where vigilance toward minor threats is crucial for survival," explained Pine.

Bias toward threats showed no such association with PTSD symptoms in those with the high efficiency version of the gene. Nor did gene type interact with threat bias to predict PTSD in solders with low combat exposure. Similarly, among the low combat exposure group, a history of traumatic experiences, self-reported combat experience, threat bias or gene type had no bearing on PTSD symptoms.

Higher pre-deployment PTSD symptoms and failure to complete high school also predicted higher post-deployment PTSD risk.

"Extreme adaptation challenges, such as those arising from soldiers' shifting exposures to relatively safe and acutely hostile environments, may produce shifting psychological and behavioral symptoms of hyper-vigilance and avoidance," explained the researchers.

They propose that computer-based attention bias modification techniques (see below) be tested in both soldiers prior to deployment as well as in PTSD patients, in combination with evidence-based cognitive therapies.


Story Source:

The above story is based on materials provided by NIH/National Institute of Mental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wald I, Degnan KA, Gorodetsky E, Charney DS, Fox NA, Fruchter E, Goldman D, Lubin G, Pine DS, Bar-Haim Y. Attention to Threats and Combat-Related Post-Traumatic Stress Symptoms: Prospective Associations and Moderation by the Serotonin Transporter Gene. JAMA Psychiatry, 2013; DOI: 10.1001/2013.jamapsychiatry.188

Cite This Page:

NIH/National Institute of Mental Health. "Threat bias interacts with combat, gene to boost PTSD risk." ScienceDaily. ScienceDaily, 13 February 2013. <www.sciencedaily.com/releases/2013/02/130213165714.htm>.
NIH/National Institute of Mental Health. (2013, February 13). Threat bias interacts with combat, gene to boost PTSD risk. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2013/02/130213165714.htm
NIH/National Institute of Mental Health. "Threat bias interacts with combat, gene to boost PTSD risk." ScienceDaily. www.sciencedaily.com/releases/2013/02/130213165714.htm (accessed October 22, 2014).

Share This



More Mind & Brain News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Working Mother Getaway: Beaches Turks & Caicos

Working Mother Getaway: Beaches Turks & Caicos

Working Mother (Oct. 22, 2014) Feast your eyes on this gorgeous family-friendly resort. Video provided by Working Mother
Powered by NewsLook.com
What Your Favorite Color Says About You

What Your Favorite Color Says About You

Buzz60 (Oct. 22, 2014) We all have one color we love to wear, and believe it or not, your color preference may reveal some of your character traits. In celebration of National Color Day, Krystin Goodwin (@kyrstingoodwin) highlights what your favorite colors may say about you. Video provided by Buzz60
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
Portable Breathalyzer Gets You Home Safely

Portable Breathalyzer Gets You Home Safely

Buzz60 (Oct. 21, 2014) Breeze, a portable breathalyzer, gets you home safely by instantly showing your blood alcohol content, and with one tap, lets you call an Uber, a cab or a friend from your contact list to pick you up. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins