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Copper can protect against Alzheimer's disease, study suggests

Date:
February 17, 2013
Source:
Keele University
Summary:
Researchers have provided unequivocal evidence that under conditions which are approximately similar to those found in the brain, copper can only protect against beta amyloid forming beta sheets and as such it is highly unlikely that copper is directly involved in the formation of senile plaques in Alzheimer's disease.

Researchers in The Birchall Centre at Keele University, Staffordshire, UK, have provided unequivocal evidence that under conditions which are approximately similar to those found in the brain, copper can only protect against beta amyloid forming beta sheets and as such it is highly unlikely that copper is directly involved in the formation of senile plaques in Alzheimer's disease.

The research, published by Nature's online journal Scientific Reports, may also imply that lower levels of copper in the brain may promote the mechanisms whereby beta amyloid is deposited as senile plaques in Alzheimer's disease.

This research addressed the on-going question as to whether copper in the brain contributes to the formation of the senile plaques in Alzheimer's disease. While previous research at Keele's Birchall Centre pointed towards copper being potentially protective in preventing the protein beta amyloid from aggregating as beta sheets and forming senile plaques it had remained a controversial issue for some.


Story Source:

The above story is based on materials provided by Keele University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Matthew Mold, Larissa Ouro-Gnao, Beata M Wieckowski, Christopher Exley. Copper prevents amyloid-β1–42 from forming amyloid fibrils under near-physiological conditions in vitro. Scientific Reports, 2013; 3 DOI: 10.1038/srep01256

Cite This Page:

Keele University. "Copper can protect against Alzheimer's disease, study suggests." ScienceDaily. ScienceDaily, 17 February 2013. <www.sciencedaily.com/releases/2013/02/130217083905.htm>.
Keele University. (2013, February 17). Copper can protect against Alzheimer's disease, study suggests. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2013/02/130217083905.htm
Keele University. "Copper can protect against Alzheimer's disease, study suggests." ScienceDaily. www.sciencedaily.com/releases/2013/02/130217083905.htm (accessed July 28, 2014).

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