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How predictable is evolution?

Date:
February 19, 2013
Source:
Public Library of Science
Summary:
Understanding how and why diversification occurs is important for understanding why there are so many species on Earth. Researchers show that similar -- or even identical -- mutations can occur during diversification in completely separate populations of E. coli evolving in different environments over more than 1000 generations. Evolution, therefore, can be surprisingly predictable.
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Under a magnification of 6836x, this colorized scanning electron micrograph (SEM) depicted a number of Gram-negative Escherichia coli bacteria of the strain O157:H7, which is one of hundreds of strains of this bacterium.
Credit: CDC/Janice Haney Carr

Understanding how and why diversification occurs is important for understanding why there are so many species on Earth. In a new study published on 19 February in the open access journal PLOS Biology, researchers show that similar -- or even identical -- mutations can occur during diversification in completely separate populations of E. coli evolving in different environments over more than 1000 generations. Evolution, therefore, can be surprisingly predictable.

The experiment, conducted by Matthew Herron, research assistant professor at the University of Montana, and Professor Michael Doebeli of the University of British Columbia, involved 3 different populations of bacteria. At the start of the experiment, each population consisted of generalists competing for two different sources of dietary carbon (glucose and acetate), but after 1200 generations they had evolved into two coexisting types each with a specialized physiology adapted to one of the carbon sources. Herron and Doebeli were able to sequence the genomes of populations of bacteria frozen at 16 different points during their evolution, and discovered a surprising amount of similarity in their evolution.

"In all three populations it seems to be more or less the same core set of genes that are causing the two phenotypes that we see," Herron said. "In a few cases, it's even the exact same genetic change."

Recent advances in sequencing technology allowed Herron and Doebeli to sequence large numbers of whole bacterial genomes and provide evidence that there is predictability in evolutionary diversity. Any evolutionary process is some combination of predictable and unpredictable processes with random mutations, but seeing the same genetic changes in different populations showed that selection can be deterministic.

"There are about 4.5 million nucleotides in the E. coli genome," he said. "Finding in four cases that the exact same change had happened independently in different populations was intriguing."

Herron and Doebeli argue that a particular form of selection -- negative frequency dependence -- plays an important role in driving diversification. When bacteria are either glucose specialists or acetate specialists, a higher density of one type will mean fewer resources for that type, so bacteria specializing on the alternative resource will be at an advantage.

"We think it's likely that some kind of negative frequency dependence -- some kind of rare type advantage -- is important in many cases of diversification, especially when there's no geographic isolation," Herron said.

As technology advances, Herron believes that similar experiments in larger organisms will soon be possible. Some examples of diversification without geographic isolation are known in plants and animals, but it remains to be seen whether or not the underlying evolutionary processes are similar to those in bacteria.


Story Source:

The above post is reprinted from materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Herron MD, Doebeli M. Parallel Evolutionary Dynamics of Adaptive Diversification in Escherichia coli. PLOS Biol, 11(2): e1001490 DOI: 10.1371/journal.pbio.1001490

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Public Library of Science. "How predictable is evolution?." ScienceDaily. ScienceDaily, 19 February 2013. <www.sciencedaily.com/releases/2013/02/130219172155.htm>.
Public Library of Science. (2013, February 19). How predictable is evolution?. ScienceDaily. Retrieved September 3, 2015 from www.sciencedaily.com/releases/2013/02/130219172155.htm
Public Library of Science. "How predictable is evolution?." ScienceDaily. www.sciencedaily.com/releases/2013/02/130219172155.htm (accessed September 3, 2015).

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