Featured Research

from universities, journals, and other organizations

Researchers link left-sided brain injury with greater risk for hospital-acquired infections

Date:
February 28, 2013
Source:
Kessler Foundation
Summary:
New findings have implications for translational research into brain-mediated immune defenses, infection control practices and cognitive rehabilitation strategies after stroke and brain injury.

Findings published in the March issue of Archives of Physical Medicine & Rehabilitation have implications for translational research into brain-mediated immune defenses, infection control practices and cognitive rehabilitation strategies after stroke and brain injury.

West Orange, NJ. February 28, 2013. The March 2013 issue of Archives of Physical Medicine & Rehabilitation, the medical journal of the American Congress of Rehabilitation Medicine, features an article by Kessler researchers Pasquale Frisina, PhD, Ann Kutlik, BA, and A.M. Barrett, MD. The study, "Left-sided brain injury associated with more hospital-acquired infections during inpatient rehabilitation," has implications for further research into brain-mediated immune defenses, infection control practices and cognitive rehabilitation strategies to improve outcomes after stroke and traumatic brain injury.

The study was supported by Kessler Foundation and the National Institutes of Health (grant nos. R01NS055808, K24HD062647).

The authors, a team of stroke specialists from Kessler Foundation and Kessler Institute for Rehabilitation, report findings of a retrospective study of 2236 inpatients with brain lesions caused by traumatic brain injury or stroke. Hospital-acquired infection (HAI), a common complication that adversely affects outcomes and costs, was defined as infection diagnosed within 48 to 72 hours of admission. Of the 163 patients identified as having hospital-acquired infections, 60.1% had left-sided lesions. This finding was consistent with the hypothesis that a left-dominant brain immune network (LD-BIN) may influence the occurrence of HAI during inpatient rehabilitation for stroke and TBI.

These findings may help healthcare providers predict who is most susceptible to HAI, according to lead author Pasquale Frisina, PhD, which could help reduce mortality rates, control costs of care and improve outcomes. "The study indicates that antisepsis may not be the best or sole method to manage infection risk after stroke and brain injury," said Dr. Frisina. "Future research should focus on ways to optimize the LD-BIN to improve health. These may include brain stimulation techniques such as direct electrical stimulation of the prefrontal brain or behavioral techniques such as mental/cognitive exercise." He added that this investigative approach might lead to novel interventions aimed at increasing infection resistance, rather than on reducing or eradicating pathogens.

"Clinicians rarely think about the brain and immunity," noted A.M. Barrett, MD, "but the balance between left and right brain activity is known to affect our infection resistance. I'm proud to be part of scientific activities that ask these kinds of innovative questions, and get answers that become the basis for new, improved processes for clinical care."

Pasquale Frisina, PhD, is director of quality management at Kessler Institute for Rehabilitation in West Orange, NJ, and assistant professor in the department of geriatrics and adult development at Mount Sinai School of Medicine in New York. Ann Kutlik, BA, is research and outcomes coordinator at Kessler Institute. A.M. Barrett, MD, is Director, Stroke Rehabilitation Research at Kessler Foundation and Chief, Neurorehabilitation Program Innovation, Kessler Institute of Rehabilitation in West Orange. Dr. Barrett is also professor of Physical Medicine and Rehabilitation at the University of Medicine and Dentistry, New Jersey Medical School, in Newark, N.J.


Story Source:

The above story is based on materials provided by Kessler Foundation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pasquale G. Frisina, Ann M. Kutlik, Anna M. Barrett. Left-Sided Brain Injury Associated With More Hospital-Acquired Infections During Inpatient Rehabilitation. Archives of Physical Medicine and Rehabilitation, 2013; 94 (3): 516 DOI: 10.1016/j.apmr.2012.10.012

Cite This Page:

Kessler Foundation. "Researchers link left-sided brain injury with greater risk for hospital-acquired infections." ScienceDaily. ScienceDaily, 28 February 2013. <www.sciencedaily.com/releases/2013/02/130228171458.htm>.
Kessler Foundation. (2013, February 28). Researchers link left-sided brain injury with greater risk for hospital-acquired infections. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2013/02/130228171458.htm
Kessler Foundation. "Researchers link left-sided brain injury with greater risk for hospital-acquired infections." ScienceDaily. www.sciencedaily.com/releases/2013/02/130228171458.htm (accessed August 28, 2014).

Share This




More Mind & Brain News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com
Alice in Wonderland Syndrome

Alice in Wonderland Syndrome

Ivanhoe (Aug. 27, 2014) It’s an unusual condition with a colorful name. Kids with “Alice in Wonderland” syndrome see sudden distortions in objects they’re looking at or their own bodies appear to change size, a lot like the main character in the Lewis Carroll story. Video provided by Ivanhoe
Powered by NewsLook.com
Stopping Schizophrenia Before Birth

Stopping Schizophrenia Before Birth

Ivanhoe (Aug. 27, 2014) Scientists have long called choline a “brain booster” essential for human development. Not only does it aid in memory and learning, researchers now believe choline could help prevent mental illness. Video provided by Ivanhoe
Powered by NewsLook.com
Personalized Brain Vaccine for Glioblastoma

Personalized Brain Vaccine for Glioblastoma

Ivanhoe (Aug. 27, 2014) Glioblastoma is the most common and aggressive brain cancer in humans. Now a new treatment using the patient’s own tumor could help slow down its progression and help patients live longer. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins