Featured Research

from universities, journals, and other organizations

Virus and genes involved in causation of schizophrenia

Date:
March 8, 2013
Source:
Aarhus University
Summary:
For the first time, researchers have found that a combination of a particular virus in the mother and a specific gene variant in the child increases the risk of the child developing schizophrenia.

Viruses and genes interact in a way that may increase the risk of developing schizophrenia significantly. This happens already in the developing fetus.

An international team of scientists led by Aarhus University, Denmark, has made this discovery. As the first in the world, they scanned the entire genome of hundreds of sick and healthy people to see if there is an interaction between genes and a very common virus -- cytomegalovirus -- and to see whether the interaction influences the risk of developing schizophrenia.

And it does.

Women that have been infected by the virus -- and around 70 % has -- will have a statistically significant increased risk of giving birth to a child who later develops schizophrenia if the child also has the aforementioned gene variant. This variant is found in 15 percent. The risk is five times higher than usual, the researchers report in Molecular Psychiatry.

No cause for alarm

People infected with cytomegalovirus most often do not know it, as the infection by the virus, which belongs to the herpes virus family, is usually very mild. But the researchers stress that there is no cause for alarm -- even if both risk factors are present in mother and child, there may be a variety of other factors that prevents disease development in the child.

But as schizophrenia affects 1 per cent of the global population, this new knowledge is very important.

"In the longer term, the development of an effective vaccine against cytomegalovirus may help to prevent many cases of schizophrenia," says Professor of Medical Genetics at Aarhus University, Anders Børglum.

"And our discovery emphasizes that mental disorders such as schizophrenia may arise in the context of an interaction between genes and biological environmental factors very early in life."


Story Source:

The above story is based on materials provided by Aarhus University. Note: Materials may be edited for content and length.


Journal Reference:

  1. A D Børglum, D Demontis, J Grove, J Pallesen, M V Hollegaard, C B Pedersen, A Hedemand, M Mattheisen, A Uitterlinden, M Nyegaard, T Ørntoft, C Wiuf, M Didriksen, M Nordentoft, M M Nöthen, M Rietschel, R A Ophoff, S Cichon, R H Yolken, D M Hougaard, P B Mortensen, O Mors. Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Molecular Psychiatry, 2013; DOI: 10.1038/mp.2013.2

Cite This Page:

Aarhus University. "Virus and genes involved in causation of schizophrenia." ScienceDaily. ScienceDaily, 8 March 2013. <www.sciencedaily.com/releases/2013/03/130308111315.htm>.
Aarhus University. (2013, March 8). Virus and genes involved in causation of schizophrenia. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/03/130308111315.htm
Aarhus University. "Virus and genes involved in causation of schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2013/03/130308111315.htm (accessed July 24, 2014).

Share This




More Mind & Brain News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) — China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com
Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) — An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) — The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins