Featured Research

from universities, journals, and other organizations

Novel drug delivery system releases drugs in response to compression by the patient's hand

Date:
March 17, 2013
Source:
National Institute for Materials Science
Summary:
Medical researchers have succeeded in developing a gel material which is capable of releasing drugs in response to pressure applied by the patient.

Conceptual scheme of controlled release of ODN from a hydrogel composed of a CyD-containing molecular network by mechanical compression.
Credit: Image courtesy of National Institute for Materials Science

A research group headed by Dr. Katsuhiko Ariga, a MANA Principal Investigator, Dr. Kohsaku Kawakami, a MANA Scientist, and Dr. Hironori Izawa, a MANA Post-Doctoral Researcher (currently Assistant Professor of Tottori University) of the NIMS International Center for Materials Nanoarchitectonics (MANA) succeeded in developing a gel material which is capable of releasing drugs in response to pressure applied by the patient.

Related Articles


Drugs are generally taken by oral administration, injection, etc. However, the conventional methods may cause side effects and inconveniences. Although stimuli-responsive drug delivery systems are an effective technique which solves such problems, a special device is necessary in order to apply the stimulus.

The MANA research group developed a gel material envisioning a new drug administration method in which the drug is released when the patient applies manual pressure to the gel. Using samples of the gel containing the anti-emetic drug ondansetron, the researchers confirmed that the drug was released when stimulus mimicking finger-pressure by the patient was applied, and found that this effect was maintained for at least 3 days. Although oral administration of drugs is difficult for patients experiencing nausea during cancer chemotherapy, if this material is introduced under the skin, it is expected to release the drug simply by pressing or rubbing it.

Because this material does not require special devices, electricity, etc., it can be used even when lifeline infrastructure has been interrupted by disasters, in developing countries where the lifeline is inherently inadequate, etc. It will also be possible for patients to administer drugs under any environment at their own intention. Many situations where patients wish to administer drugs quickly "on-demand" are also assumed, for example, for relief from cancer pain, hay fever, or asthma. Thus, this material offers an extremely convenient new dosing strategy.

The gel is produced by crosslinking calcium alginate, which is a naturally-derived component contained in algae, with cyclodextrin, which is a saccharide. Both substances are already used in pharmaceuticals. Cyclodextrin hosts a drug as a guest. This is the first report in which a host-guest interaction is controlled by mechanical stimulus.

These results were published in the online bulletin of the English scientific journal Journal of Materials Chemistry B.


Story Source:

The above story is based on materials provided by National Institute for Materials Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hironori Izawa, Kohsaku Kawakami, Masato Sumita, Yoshitaka Tateyama, Jonathan P. Hill, Katsuhiko Ariga. β-Cyclodextrin-crosslinked alginate gel for patient-controlled drug delivery systems: regulation of host–guest interactions with mechanical stimuli. Journal of Materials Chemistry B, 2013; DOI: 10.1039/C3TB00503H

Cite This Page:

National Institute for Materials Science. "Novel drug delivery system releases drugs in response to compression by the patient's hand." ScienceDaily. ScienceDaily, 17 March 2013. <www.sciencedaily.com/releases/2013/03/130317154716.htm>.
National Institute for Materials Science. (2013, March 17). Novel drug delivery system releases drugs in response to compression by the patient's hand. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2013/03/130317154716.htm
National Institute for Materials Science. "Novel drug delivery system releases drugs in response to compression by the patient's hand." ScienceDaily. www.sciencedaily.com/releases/2013/03/130317154716.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins