Featured Research

from universities, journals, and other organizations

Did evolution give us inflammatory disease?

Date:
March 22, 2013
Source:
Brigham and Women's Hospital
Summary:
Researchers demonstrate that some variants in our genes which could put a person at risk for inflammatory diseases -- such as multiple sclerosis, Crohn's disease or rheumatoid arthritis -- have been the target of natural selection over the course of human history.

In new research published in the April 4, 2013 issue of The American Journal of Human Genetics, researchers from Brigham and Women's Hospital (BWH) demonstrate that some variants in our genes that could put a person at risk for inflammatory diseases such as multiple sclerosis, Crohn's disease or rheumatoid arthritis, have been the target of natural selection over the course of human history.

The research team, led by Philip De Jager, MD, PhD, BWH Department of Neurology, and Barbara Stranger, PhD, University of Chicago looked at genome-wide association studies along with protein-protein interaction networks, as well as other data and found 21 places in the genome that bear a 'signature' for both inflammatory disease susceptibility and natural selection.

Towfique Raj, PhD, BWH Department of Neurology, is the lead author on this study. The findings suggest that in the past these variants rose in frequency in the human population to help protect us against viruses, bacteria and other pathogens. But now in our modern world, the environment and exposure to pathogens has changed, and the genetic variants that were originally meant to protect us, now make an autoimmune reaction more likely. These results are consistent with the hygiene hypothesis in which our cleaner environment is thought to contribute to the increasing prevalence of inflammatory diseases.


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Towfique Raj, Manik Kuchroo, JosephM. Replogle, Soumya Raychaudhuri, BarbaraE. Stranger, PhilipL. DeJager. Common Risk Alleles for Inflammatory Diseases Are Targets of Recent Positive Selection. The American Journal of Human Genetics, 2013; DOI: 10.1016/j.ajhg.2013.03.001

Cite This Page:

Brigham and Women's Hospital. "Did evolution give us inflammatory disease?." ScienceDaily. ScienceDaily, 22 March 2013. <www.sciencedaily.com/releases/2013/03/130322104255.htm>.
Brigham and Women's Hospital. (2013, March 22). Did evolution give us inflammatory disease?. ScienceDaily. Retrieved September 29, 2014 from www.sciencedaily.com/releases/2013/03/130322104255.htm
Brigham and Women's Hospital. "Did evolution give us inflammatory disease?." ScienceDaily. www.sciencedaily.com/releases/2013/03/130322104255.htm (accessed September 29, 2014).

Share This



More Health & Medicine News

Monday, September 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Why Is Big Tobacco Voluntarily Warning You About E-Cigs?

Why Is Big Tobacco Voluntarily Warning You About E-Cigs?

Newsy (Sep. 29, 2014) Big tobacco companies are voluntarily printing health warnings on their e-cigarette packages — a move some are calling part of a PR strategy. Video provided by Newsy
Powered by NewsLook.com
Why Pediatricians Endorse IUDs, Implants For Teens

Why Pediatricians Endorse IUDs, Implants For Teens

Newsy (Sep. 29, 2014) New recommendations from the American Academy of Pediatrics point to intrauterine devices and implants as good forms of birth control for teens. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins