Featured Research

from universities, journals, and other organizations

Genetic biomarker may help identify neuroblastomas vulnerable to novel class of drugs

Date:
April 9, 2013
Source:
Dana-Farber Cancer Institute
Summary:
An irregularity within many neuroblastoma cells may indicate whether the tumor is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors

An irregularity within many neuroblastoma cells may indicate whether a neuroblastoma tumor, a difficult-to-treat, early childhood cancer, is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors, Dana-Farber/Children's Hospital Cancer Center scientists will report at the annual meeting of the American Association for Cancer Research in Washington, April 6-10.

The findings (abstract 4622) will be discussed in a minisymposium on Tuesday, April 9, 3:50 -- 4:05 p.m., ET, in Room 147, in the Washington Convention Center. The work was published in Cancer Discovery, a journal of the American Association of Cancer Research, on Feb. 21, 2013.

In studies with laboratory samples of neuroblastoma cells and mice with the disease, the researchers found that tumors with excess copies, or "amplification," of the gene MYCN were highly sensitive to BET bromodomain inhibitors. The findings may lead to clinical trials of the drugs in patients whose neuroblastoma tumors carry this amplification.

"BET bromodomain inhibitors are a class of drugs that, many researchers hope, may offer a new therapeutic option for treating patients with certain cancers," says Dana-Farber/Children's Hospital Cancer Center researcher and clinician Kimberly Stegmaier, MD, who will be presenting the research. "The challenge has been identifying biomarkers that can help direct clinical translation of these drugs by pinpointing those patients with the highest likelihood of response."

Stegmaier and her colleagues screened more than 600 cancer cell lines, each with a known set of genetic abnormalities, to see which would succumb to a prototype BET bromodomain inhibitor. They found the most susceptible cells were those with a MYCN amplification.

"Neuroblastoma is a devastating childhood cancer -- the most common extracranial tumor of early childhood -- and only a minority of children with aggressive forms of the disease are cured with currently available treatments," Stegmaier remarks. "Although prior research has shown that MYCN amplification is common in neuroblastoma, it has been an elusive drug target."

Working with Dana-Farber's James Bradner, MD, Stegmaier found that the BET bromodomain inhibitor reduced the levels of MYCN protein in lab-grown neuroblastoma cells, resulting in impaired cell growth and induction of cell death. In studies of mice with MYCN-amplified neuroblastoma -- including animals with a form of the disease that doesn't respond to many standard therapies -- the drug had anti-tumor effects and prolonged survival.

The research was funded in part by the V Foundation for Cancer Research; a Friends for Life Fellowship; the Howard Hughes Medical Institute; the Damon Runyon Cancer Research Foundation; the Smith Family Foundation; Alex's Lemonade Stand; the National Institutes of Health (grants R01CA102321, P01CA081403, K08NS079485, and T32CA1510220; and the Samuel Waxman Cancer Research Foundation. Stegmaier is also supported by a Stand Up to Cancer Innovative Research Grant, a program of the Entertainment Industry Foundation (SU2C-AACR-IRG0509).


Story Source:

The above story is based on materials provided by Dana-Farber Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Dana-Farber Cancer Institute. "Genetic biomarker may help identify neuroblastomas vulnerable to novel class of drugs." ScienceDaily. ScienceDaily, 9 April 2013. <www.sciencedaily.com/releases/2013/04/130409173400.htm>.
Dana-Farber Cancer Institute. (2013, April 9). Genetic biomarker may help identify neuroblastomas vulnerable to novel class of drugs. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2013/04/130409173400.htm
Dana-Farber Cancer Institute. "Genetic biomarker may help identify neuroblastomas vulnerable to novel class of drugs." ScienceDaily. www.sciencedaily.com/releases/2013/04/130409173400.htm (accessed August 2, 2014).

Share This




More Health & Medicine News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins