Featured Research

from universities, journals, and other organizations

First objective measure of pain discovered in brain scan patterns

Date:
April 10, 2013
Source:
University of Colorado at Boulder
Summary:
For the first time, scientists have been able to predict how much pain people are feeling by looking at images of their brains, according to a new study led by the University of Colorado Boulder.

The neurologic signature for physical pain has been identified in a new study.
Credit: Tor Wager

For the first time, scientists have been able to predict how much pain people are feeling by looking at images of their brains, according to a new study led by the University of Colorado Boulder.

Related Articles


The findings, published onApril 10 in the New England Journal of Medicine, may lead to the development of reliable methods doctors can use to objectively quantify a patient's pain. Currently, pain intensity can only be measured based on a patient's own description, which often includes rating the pain on a scale of one to 10. Objective measures of pain could confirm these pain reports and provide new clues into how the brain generates different types of pain.

The new research results also may set the stage for the development of methods using brain scans to objectively measure anxiety, depression, anger or other emotional states.

"Right now, there's no clinically acceptable way to measure pain and other emotions other than to ask a person how they feel," said Tor Wager, associate professor of psychology and neuroscience at CU-Boulder and lead author of the paper.

The research team, which included scientists from New York University, Johns Hopkins University and the University of Michigan, used computer data-mining techniques to comb through images of 114 brains that were taken when the subjects were exposed to multiple levels of heat, ranging from benignly warm to painfully hot. With the help of the computer, the scientists identified a distinct neurologic signature for the pain.

"We found a pattern across multiple systems in the brain that is diagnostic of how much pain people feel in response to painful heat." Wager said.

Going into the study, the researchers expected that if a pain signature could be found it would likely be unique to each individual. If that were the case, a person's pain level could only be predicted based on past images of his or her own brain. But instead, they found that the signature was transferable across different people, allowing the scientists to predict how much pain a person was being caused by the applied heat, with between 90 and 100 percent accuracy, even with no prior brain scans of that individual to use as a reference point.

The scientists also were surprised to find that the signature was specific to physical pain. Past studies have shown that social pain can look very similar to physical pain in terms of the brain activity it produces. For example, one study showed that the brain activity of people who have just been through a relationship breakup -- and who were shown an image of the person who rejected them -- is similar to the brain activity of someone feeling physical pain.

But when Wager's team tested to see if the newly defined neurologic signature for heat pain would also pop up in the data collected earlier from the heartbroken participants, they found that the signature was absent.

Finally, the scientists tested to see if the neurologic signature could detect when an analgesic was used to dull the pain. The results showed that the signature registered a decrease in pain in subjects given a painkiller.

The results of the study do not yet allow physicians to quantify physical pain, but they lay the foundation for future work that could produce the first objective tests of pain by doctors and hospitals. To that end, Wager and his colleagues are already testing how the neurologic signature holds up when applied to different types of pain.

"I think there are many ways to extend this study, and we're looking to test the patterns that we've developed for predicting pain across different conditions," Wager said. "Is the predictive signature different if you experience pressure pain or mechanical pain, or pain on different parts of the body?

"We're also looking towards using these same techniques to develop measures for chronic pain. The pattern we have found is not a measure of chronic pain, but we think it may be an 'ingredient' of chronic pain under some circumstances. Understanding the different contributions of different systems to chronic pain and other forms of suffering is an important step towards understanding and alleviating human suffering."

The study was funded by the National Institute on Drug Abuse, the National Institute of Mental Health and the National Science Foundation.


Story Source:

The above story is based on materials provided by University of Colorado at Boulder. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tor D. Wager, Lauren Y. Atlas, Martin A. Lindquist, Mathieu Roy, Choong-Wan Woo, Ethan Kross. An fMRI-Based Neurologic Signature of Physical Pain. New England Journal of Medicine, 2013; 368 (15): 1388 DOI: 10.1056/NEJMoa1204471

Cite This Page:

University of Colorado at Boulder. "First objective measure of pain discovered in brain scan patterns." ScienceDaily. ScienceDaily, 10 April 2013. <www.sciencedaily.com/releases/2013/04/130410201839.htm>.
University of Colorado at Boulder. (2013, April 10). First objective measure of pain discovered in brain scan patterns. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2013/04/130410201839.htm
University of Colorado at Boulder. "First objective measure of pain discovered in brain scan patterns." ScienceDaily. www.sciencedaily.com/releases/2013/04/130410201839.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
Indians Muck in for Cleaner Communities

Indians Muck in for Cleaner Communities

AFP (Nov. 22, 2014) India's government is urging all citizens to come together in a mass movement to clean the nation -- but will people heed the call? Duration: 02:39 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins