Featured Research

from universities, journals, and other organizations

Bone marrow stromal cell treatment improves functional outcome, helps repair biostructural damage from traumatic brain injury

Date:
April 30, 2013
Source:
American Association of Neurological Surgeons (AANS)
Summary:
Results show positive impact that bone marrow stromal cell therapy can have for those suffering from certain types of traumatic brain injuries.

Today during the 81st American Association of Neurological Surgeons (AANS) Annual Scientific Meeting, researchers presented results showing the positive impact that bone marrow stromal cell (MSC) therapy can have for those suffering from certain types of traumatic brain injuries (TBIs).

The study investigated the effects of treatment with bone MSC on axonal sprouting in the spinal cord after TBI. The axonal regeneration that occurred was correlated with functional recovery. Researchers used adult male Wistar rats (n=8), which were injured with controlled cortical impact and treated with MSCs (3x10 6) impregnated into collagen scaffolds and transplanted into the lesion cavity one week after TBI. Control animals (n=8) were injected intracerebrally with saline. On day 21 after TBI, biotinylated dextran amine (BDA, 10,000 MW) was injected into the collateral motor cortex stereotactically to label the corticospinal tract (CST). Sensorimotor function was tested with neurological severity scores (NSS) and foot fault tests. All rats were sacrificed 35 days after TBI, with the brain and spinal cord sections stained for immuhohistological analysis. The results of this study, Treatment of traumatic brain injury with marrow stromal cells induces axonal sprouting in denervated spinal cord, will be presented by Asim Mahmood, MD, FAANS on Tuesday, April 30. Co-authors are Hongtao Wu, MD; Changsheng Qu, MD; and Ye Xiong, MD.

Those results found very few BDA-labeled CST fibers crossing over the midline in the spinal cord transverse sections of the control rats. However, MSC treatment significantly increased axonal sprouting from the intact CST into the denervated side of the spinal cord at both the cervical and lumbar levels (p, less than 0.05). Functional analysis showed significant improvement with NSS (p, less than 0.05) and foot fault tests (p, less than 0.05) in MSC-treated rats. Pearson's correlation data showed significant correlation between the number of crossing CST fibers and sensorimotor recovery (p, less than 0.05). The researchers concluded that MSC treatment increases axonal sprouting into the denervated side of the spinal cord after TBI, and this is at least partially responsible for the therapeutic benefits of MSC treatment of TBI.

"We have conducted several studies, short- and long-term, which showed very significant sensorimotor recovery," said Asim Mahmood, MD, FAANS, who cited 11 different studies [available upon request from John Iwanski]. "We used multimodality testing to analyze different neurological functions such as learning, memory, (Moris water maze test) and sensorimotor function (NSS and foot fault tests), and recovery was shown consistently. Further studies are not needed to substantiate the functional benefits of this therapy. What is still needed are mechanistic studies to investigate how the MSC treatment promotes functional recovery, and this is what our present research focuses on."

"Our data clearly shows that MSC treatment improves functional outcome and repairs biostructural damage resulting from TBI," added Dr. Mahmood. "This is translation research and clinical trials can be designed to use MSCs to treat TBI. MSC treatment has already been used in cardiovascular medicine."


Story Source:

The above story is based on materials provided by American Association of Neurological Surgeons (AANS). Note: Materials may be edited for content and length.


Cite This Page:

American Association of Neurological Surgeons (AANS). "Bone marrow stromal cell treatment improves functional outcome, helps repair biostructural damage from traumatic brain injury." ScienceDaily. ScienceDaily, 30 April 2013. <www.sciencedaily.com/releases/2013/04/130430131106.htm>.
American Association of Neurological Surgeons (AANS). (2013, April 30). Bone marrow stromal cell treatment improves functional outcome, helps repair biostructural damage from traumatic brain injury. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2013/04/130430131106.htm
American Association of Neurological Surgeons (AANS). "Bone marrow stromal cell treatment improves functional outcome, helps repair biostructural damage from traumatic brain injury." ScienceDaily. www.sciencedaily.com/releases/2013/04/130430131106.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins