Featured Research

from universities, journals, and other organizations

Gastric bypass findings could lead to diabetes treatment

Date:
May 1, 2013
Source:
Lund University
Summary:
Scientists have shed new light on why gastric bypass often sends diabetes into remission rapidly, opening the door to developing treatment with the same effect.

A Lund University research team has shed new light on why gastric bypass often sends diabetes into remission rapidly, opening the door to developing treatment with the same effect.

Related Articles


85% of patients with type 2 diabetes who undergo a gastric bypass procedure recover from the disease within a few days, showing a return to normal blood sugar levels -- long before any weight loss. Until now, there have been few clues as to why this happens.

"Most previous studies have analysed samples taken from patients before and after a gastric bypass, but there is a risk that the results are misleading. They may not be attributable to the operation itself, but rather to factors such as weight loss and reduced food intake," says Nils Wierup of the Lund University Diabetes Centre in Sweden.

In a gastric bypass, food bypasses the majority of the stomach and duodenum. Just a small part of the upper stomach is connected directly to the small intestine. In some cases, the surgeon inserts a catheter into the part of the stomach that no longer has contact with food as a precautionary measure. This was what gave the researchers an opportunity to study the exact difference between food intake before and after the procedure.

The participants were given a set amount of a nutritional drink and blood samples were taken before, during and at short intervals after it was ingested. The next step was to inject the same amount of nutritional solution through the catheter over the same length of time as it had taken the patient to drink it and the same samples were taken. The food then ended up where it would have been before the gastric bypass.

The comparison revealed a major difference. "When the patient drank the solution, the insulin levels in the blood rose almost five times as much as when it was injected into the closed-off stomach. Intestinal hormones, which play a significant role in controlling blood sugar levels, rose sharply, as did certain amino acids. There was also a major impact on blood lipids, with the levels roughly halved," says Nils Wierup, observing:"We believe these changes are part of the answer to why gastric bypass cures type 2 diabetes. We have looked at just a few intestinal hormones. There may be a hundred or more involved in the body's complex sugar metabolism."

Jan Hedenbro, one of the surgeons in the study, adds: "If we can identify the mechanism behind this, it will open the way for both more individually tailored operations and, in the long run, the possibility of achieving the same results with pills rather than with surgery."


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andreas Lindqvist, Peter Sp้gel, Mikael Ekelund, Hindrik Mulder, Leif Groop, Jan Hedenbro and Nils Wierup. Effects of Ingestion Routes on Hormonal and Metabolic Profiles in Gastric-Bypassed Humans. JCEM, 2013 DOI: 10.1210/jc.2012-3996

Cite This Page:

Lund University. "Gastric bypass findings could lead to diabetes treatment." ScienceDaily. ScienceDaily, 1 May 2013. <www.sciencedaily.com/releases/2013/05/130501090648.htm>.
Lund University. (2013, May 1). Gastric bypass findings could lead to diabetes treatment. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2013/05/130501090648.htm
Lund University. "Gastric bypass findings could lead to diabetes treatment." ScienceDaily. www.sciencedaily.com/releases/2013/05/130501090648.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins