Featured Research

from universities, journals, and other organizations

High-resolution diffusion MRI can help map the microstructure of the trigeminal nerve, improve treatment options for trigeminal neuralgia sufferers

Date:
May 1, 2013
Source:
American Association of Neurological Surgeons (AANS)
Summary:
Researchers describe their study regarding the use of high-resolution diffusion MRI to evaluate the microstructure of the cranial nerves, and how it offers exciting possibilities to further the understanding of the pathophysiology of trigeminal neuralgia and, ultimately, improve available treatments.

Recently during the 81st American Association of Neurological Surgeons (AANS) Annual Scientific Meeting, researchers described their study regarding the use of high-resolution diffusion MRI to evaluate the microstructure of the cranial nerves.

The researchers noted that the pathophysiology of trigeminal neuralgia (TN) remains unknown and present treatments are conducted based on empirical evidence. Up to now, MRI has only been used to exclude other pathological conditions such as skull base tumors -- which can mimic TN -- but not to localize the affected area, improve treatment methods or evaluate the effects of such procedures.

For the study, researchers sought out to demonstrate the feasibility and advantages of ultra-high field diffusion MRI at the skull base, which could lead to improved TN characterization. Healthy volunteers were scanned on a 7T Siemens scanner with the following protocol: T1-, T2- and PD-weighted structural MRI with resolution 0.3x0.3x0.6mm3; diffusion MRI with 0.6x0.6mm2 in-plane resolution, 18 slices of 1.2mm, 100 gradient directions at b-value=1000s/mm2, 11 non-diffusion-weighted images, and TR/TE=5000/64ms. The results of this study, High-Resolution diffusion MRI of the Trigeminal Nerve using 7T MRI, will be presented by Andrew Grande, MD on May 1. Co-authors are Christophe Lenglet, PhD; Julien Sein, PhD; Julian Tokarev; Bharathi Jagadeesan, MD; and Pierre-Franηois Van de Moortele, MD, PhD.

The researchers' imaging protocol generated high-resolution FA and ADC maps, as well as fiber orientation estimates successfully used to characterize the microstructure of the trigeminal nerve and its divisions at the skull base using deterministic and probabilistic tractography algorithms. The researchers concluded that their findings open up new possibilities for further understanding of the pathophysiology of TN, with the prospect of improving treatments based on this new knowledge.

"Trigeminal neuralgia is a rare disease with only 150,000 new cases per year, and has been described as perhaps the worse pain imaginable. Most patients experience shock or lightning-like shocks in their face triggered by various stimuli such as eating, wind, brushing teeth or just simply talking. Patients fear this stimuli and consequently avoid eating, or going outside or talking," said Andrew Grande, MD. "In this study, we have investigated the feasibility and advantages of ultra-high field magnetic resonance imaging (MRI), at 7 Tesla, of the skull base. 7T MRI, by comparison with clinical imaging typically performed at 1.5T or 3T, provides greater image resolution and contrast, thereby improving our ability to identify and assess the integrity of structures like the trigeminal nerve. More specifically, we have focused on high-resolution diffusion MRI, which characterizes the three-dimensional configuration and microstructural properties of axonal pathways. This work opens new and exciting possibilities to further our understanding of the pathophysiology of trigeminal neuralgia and, ultimately, improve available treatments. In the future, in addition to aiding our understanding of the pathophysiology of trigeminal neuralgia, such imaging may allow us to better diagnose and could potentially be used to guide some forms of treatment directly to the afflicted portion of the nerve."


Story Source:

The above story is based on materials provided by American Association of Neurological Surgeons (AANS). Note: Materials may be edited for content and length.


Cite This Page:

American Association of Neurological Surgeons (AANS). "High-resolution diffusion MRI can help map the microstructure of the trigeminal nerve, improve treatment options for trigeminal neuralgia sufferers." ScienceDaily. ScienceDaily, 1 May 2013. <www.sciencedaily.com/releases/2013/05/130501144427.htm>.
American Association of Neurological Surgeons (AANS). (2013, May 1). High-resolution diffusion MRI can help map the microstructure of the trigeminal nerve, improve treatment options for trigeminal neuralgia sufferers. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2013/05/130501144427.htm
American Association of Neurological Surgeons (AANS). "High-resolution diffusion MRI can help map the microstructure of the trigeminal nerve, improve treatment options for trigeminal neuralgia sufferers." ScienceDaily. www.sciencedaily.com/releases/2013/05/130501144427.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) — You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) — Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) — New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins