Featured Research

from universities, journals, and other organizations

Now we know why old scizophrenia medicine works on antibiotics-resistant bacteria

Date:
May 18, 2013
Source:
University of Southern Denmark
Summary:
An old medicine for schizophrenia is effective at treating something completely different than it was designed for: antibiotic-resistant bacteria. So far it has been a mystery how this old schizophrenia medicine works, but now researchers have figured it out. This can lead to a new medicine against the increasingly threatening antibiotic-resistant bacteria.

In 2008 researchers from the University of Southern Denmark showed that the drug thioridazine, which has previously been used to treat schizophrenia, is also a powerful weapon against antibiotic-resistant bacteria such as staphylococci (Staphylococcus aureus).

Related Articles


Antibiotic-resistant bacteria is a huge problem all over the world: For example, 25 -- 50 per cent of the inhabitants in southern Europe are resistant to staphylococci. In the Scandinavian countries it is less than 5 per cent, but also here the risk of resistance is on the rise.

So any effective anti-inflammatory candidate is important to investigate -- even if the candidate is an antipsychotic that was originally developed to alleviate one of the hardest mental illnesses, schizophrenia.

Until now, scientists could only see that thioridazine works effectively and that it can kill staphylococcus bacteria in a flask in the laboratory, but now a new study reveals why and how thioridazine works. The research group, which includes professor Hans Jψrn Kolmos, associate professor Birgitte H. Kallipolitis and other participants from the Department of Biochemistry and Molecular Biology and Institute of Clinical Medicine, University of Southern Denmark, publishes their findings in the journal PLOS ONE on May 17 2013.

The research team tested thioridazine on staphylococcal bacteria and discovered that thioridazine works by weakening the bacterial cell wall.

"When we treat the bacteria with antibiotics alone, nothing happens -- the bacteria are not even affected. But when we add both thioridazine and antibiotics, something happens: thioridazine weakens the bacterial cell wall by removing glycine (an amino acid) from the cell wall. In the absence of glycine, the antibiotics can attack the weakened cell wall and kill staphylococcus bacteria," explains Janne Kudsk Klitgaard, visiting scholar at the Department of Biochemistry and Molecular Biology, University of Southern Denmark.

Thus, it is the interaction between thioridazine and antibiotic that works.

And now that researchers know that thioridazine works by weakening staphylococcal cell wall, they can concentrate on improving this ability.

"Now that we know how thioridazine works, we can develop drugs that target the resistant bacteria. And just as important: We can remove or inactivate the parts of thioridazine, which treats schizophrenia, so we end up with a brand new product that is no longer an antipsychotic, "explains Janne Kudsk Klitgaard.

According to her, we are now a little closer to a safe, non-psychopharmacological drug that can save people from potentially fatal infections that do not respond to antibiotics.

"This will no longer be an antipsychotic, when scientists are finished with this task," she says.

Together with her colleagues Klitgaard tested thioridazine on roundworms in the laboratory and have seen that they were cured of staphylococci in the gut. Next step will be testing on mice and pigs.


Story Source:

The above story is based on materials provided by University of Southern Denmark. The original article was written by Birgitte Svennevig. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mette Thorsing, Janne K. Klitgaard, Magda L. Atilano, Marianne N. Skov, Hans Jψrn Kolmos, Sιrgio R. Filipe, Birgitte H. Kallipolitis. Thioridazine Induces Major Changes in Global Gene Expression and Cell Wall Composition in Methicillin-Resistant Staphylococcus aureus USA300. PLoS ONE, 2013; 8 (5): e64518 DOI: 10.1371/journal.pone.0064518

Cite This Page:

University of Southern Denmark. "Now we know why old scizophrenia medicine works on antibiotics-resistant bacteria." ScienceDaily. ScienceDaily, 18 May 2013. <www.sciencedaily.com/releases/2013/05/130518153742.htm>.
University of Southern Denmark. (2013, May 18). Now we know why old scizophrenia medicine works on antibiotics-resistant bacteria. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/05/130518153742.htm
University of Southern Denmark. "Now we know why old scizophrenia medicine works on antibiotics-resistant bacteria." ScienceDaily. www.sciencedaily.com/releases/2013/05/130518153742.htm (accessed October 25, 2014).

Share This



More Plants & Animals News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) — Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) — Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) — One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) — Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins