Featured Research

from universities, journals, and other organizations

Breakthrough on Huntington's disease

Date:
May 23, 2013
Source:
Lund University
Summary:
Researchers have succeeded in preventing very early symptoms of Huntington’s disease, depression and anxiety, by deactivating the mutated huntingtin protein in the brains of mice.

Researchers at Lund University have succeeded in preventing very early symptoms of Huntington's disease, depression and anxiety, by deactivating the mutated huntingtin protein in the brains of mice.

Related Articles


"We are the first to show that it is possible to prevent the depression symptoms of Huntington's disease by deactivating the diseased protein in nerve cell populations in the hypothalamus in the brain. This is hugely exciting and bears out our previous hypotheses," explains Ĺsa Petersén, Associate Professor of Neuroscience at Lund University.

Huntington's is a debilitating disease for which there is still neither cure nor sufficient treatment. The dance-like movements that characterise the disease have long been the focus for researchers, but the emotional problems affect the patient earlier than the motor symptoms. These are now believed to stem from a different part of the brain -- the small emotional centre called the hypothalamus.

"Now that we have been able to show in animal experiments that depression and anxiety occur very early in Huntington's disease, we want to identify more specifically which nerve cells in the hypothalamus are critical in the development of these symptoms. In the long run, this gives us better opportunities to develop more accurate treatments that can attack the mutated huntingtin where it does the most damage," says Ĺsa Petersén.

As the role of the hypothalamus in Huntington's disease is gradually mapped, knowledge might be gained from drug research for other psychiatric diseases. It is likely that similar mechanisms control different types of depression, according to Ĺsa Petersén.


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Hult Lundh, N. Nilsson, R. Soylu, D. Kirik, A. Petersen. Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease. Human Molecular Genetics, 2013; DOI: 10.1093/hmg/ddt203

Cite This Page:

Lund University. "Breakthrough on Huntington's disease." ScienceDaily. ScienceDaily, 23 May 2013. <www.sciencedaily.com/releases/2013/05/130523082927.htm>.
Lund University. (2013, May 23). Breakthrough on Huntington's disease. ScienceDaily. Retrieved November 21, 2014 from www.sciencedaily.com/releases/2013/05/130523082927.htm
Lund University. "Breakthrough on Huntington's disease." ScienceDaily. www.sciencedaily.com/releases/2013/05/130523082927.htm (accessed November 21, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, November 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Your Complicated Job Might Keep Your Brain Young

Your Complicated Job Might Keep Your Brain Young

Newsy (Nov. 20, 2014) — Researchers at the University of Edinburgh found the more complex your job is, the sharper your cognitive skills will likely be as you age. Video provided by Newsy
Powered by NewsLook.com
100-Year-Old Woman Sees Ocean for First Time

100-Year-Old Woman Sees Ocean for First Time

AP (Nov. 20, 2014) — Ruby Holt spent most of her 100 years on a farm in rural Tennessee, picking cotton and raising four children. She saw the ocean for the first time thanks to her assisted living center and a group that grants wishes to the elderly. (Nov. 20) Video provided by AP
Powered by NewsLook.com
Kids React to Lammily, The Realistic Barbie Alternative

Kids React to Lammily, The Realistic Barbie Alternative

Buzz60 (Nov. 19, 2014) — Artist Nickolay Lamm's Kickstarter-funded Lammily doll, based on his 'What Would Barbie Look Like as a Real Woman' project, is finally available to buy. Jen Markham explains how the doll's realistic proportions are going over with a test group of second-graders who are used to the impossible measurements of Barbie dolls. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins