Featured Research

from universities, journals, and other organizations

Removing nerves connecting kidney to the brain shown to reduce high blood pressure

Date:
July 1, 2013
Source:
University of Bristol
Summary:
A new technique that involves removing the nerves connecting the kidney to the brain has shown to significantly reduce blood pressure and help lower the risk of stroke, heart and renal disease in patients.

A new technique that involves removing the nerves connecting the kidney to the brain has shown to significantly reduce blood pressure and help lower the risk of stroke, heart and renal disease in patients. The procedure, which has very few side effects, has already shown promising results in hard-to-treat cases of high blood pressure.

Related Articles


The technique, published in the journal Hypertension, was performed by a team led by Professor Julian Paton at the University of Bristol who found that in an animal model of hypertension removing nerves connecting the kidney to the brain reduced blood pressure and improved its long-term stability.

Inspired by these results, cardiologists Dr Angus Nightingale and Dr Andreas Baumbach from the Bristol Heart Institute (BHI) adopted the technique called "renal denervation" to remove the nerves to the kidney in patients with high blood pressure.

The procedure, which has been successfully trialled on 19 patients at the BHI, is performed using a fine tube that is inserted in an artery in the patient's leg and positioned in the artery feeding blood to the patient's kidneys. The nerves to the kidney are around the artery and ablated by radio-frequency energy that is emitted from the tube.

The breakthrough is due to a new collaboration involving scientists at the University of Bristol and cardiologists at the BHI, who have joined forces to form the CardioNomics high blood pressure team. Together, they hope to tackle this major health problem by taking findings from the laboratory and translating them into clinical practice. The CardioNomics team have just been awarded 100,000 grant from Medtronic to further improve the technique and expand patient trials.

Dr Nightingale, who runs the Specialist Hypertension Clinic at the BHI, said: "We have used renal denervation in patients who have hard-to-treat blood pressure. Similar to the results from the basic science experiments, we have also seen reductions in blood pressure which has been essential for reducing the risk of heart and renal disease, and stroke in our patients. This is an exciting new treatment for these patients who have struggled with high blood pressure which tablets are not controlling."

Dr Baumbach, an interventional cardiologist who performed the treatment, added: "The technique is very straight forward, performed as a day case and there are no side-effects. It is becoming a popular technique for patients with both resistance and poor tolerability to high blood pressure medication."

Professor Julian Paton, who led the research at the University's School of Physiology and Pharmacology, said: "The problem with high blood pressure is that patients develop resistance to their tablets or unpleasant side effects. Our new interventional approaches are based on studies where we have found causative mechanisms generating high blood pressure so we think that they will be most efficacious in patients. And, with luck, they will also mean less pill taking too."


Story Source:

The above story is based on materials provided by University of Bristol. Note: Materials may be edited for content and length.


Journal Reference:

  1. Emma C. Hart, Fiona D. McBryde, Amy E. Burchell, Laura E.K. Ratcliffe, Lesley Q. Stewart, Andreas Baumbach, Angus Nightingale, and Julian F.R. Paton. Translational Examination of Changes in Baroreflex Function After Renal Denervation in Hypertensive Rats and Humans. Hypertension, July 1 2013 DOI: 10.1161/HYPERTENSIONAHA.113.01261

Cite This Page:

University of Bristol. "Removing nerves connecting kidney to the brain shown to reduce high blood pressure." ScienceDaily. ScienceDaily, 1 July 2013. <www.sciencedaily.com/releases/2013/07/130701163849.htm>.
University of Bristol. (2013, July 1). Removing nerves connecting kidney to the brain shown to reduce high blood pressure. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2013/07/130701163849.htm
University of Bristol. "Removing nerves connecting kidney to the brain shown to reduce high blood pressure." ScienceDaily. www.sciencedaily.com/releases/2013/07/130701163849.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins