Featured Research

from universities, journals, and other organizations

Molecular explanation for degenerative disease proposed

Date:
August 16, 2013
Source:
Trinity College Dublin
Summary:
Scientists have shed new light on the origins and molecular causes of age related degenerative conditions including motor neuron disease. The new perspective provided by this work may lead the way to new treatments and early diagnoses.

An international collaboration jointly led by scientists from Trinity College Dublin has shed new light on the origins and molecular causes of age related degenerative conditions including Motor Neuron Disease (MND). The new perspective provided by this work may lead the way to new treatments and early diagnoses.

The article which has just been published in the leading peer reviewed, international journal Cell, offers new opportunities for early diagnosis of age related degenerative diseases before symptoms appear, including through the identification of disease causing genes. It also suggests specific strategies for developing therapies which might have both preventative and therapeutic benefits for this class of degenerative disease.

Commenting on the significance of the findings co-lead author Professor Mani Ramaswami, Professor of Neurogenetics at the School of Genetics and Microbiology, Trinity College Dublin said: "Degenerative diseases, such as MND, are a poorly understood and largely untreatable set of life limiting diseases which can leave people unable to do the everyday things that the rest of us, particularly the young, take for granted. These age-associated diseases have far-reaching socioeconomic impacts. If you can predict the disease you may be in a position to slow down its onset and progression through therapeutic interventions. With these types of diseases this is significantly more effective than trying to treat the condition once symptoms have appeared. The potential for early diagnosis and delaying the onset of motor or cognitive decline by perhaps ten years is of potentially profound importance in an aging society."

There are nearly 120,000 cases of MND diagnosed worldwide each year with about 300 people in Ireland living with the disease at any one time.

The research just published proposes that the normal biology of mRNA regulation in neurons, in which RNA is generally silenced and only activated in the correct place and time, makes it susceptible to both age-related decline and disturbance by genetic mutation. Altered RNA regulation (ribostasis), therefore, may be a frequent causative factor in degenerative disease. While normal RNA regulation involves regulated and reversible assembly of RNA-protein particles, both increased cellular age and mutation push the process towards hyperassembly, which leads to altered pools of RNA or RNA regulatory proteins in neurons that contribute to their eventual death. Co-authors of the publication, Professors Ramaswami, Taylor (St. Jude Children's Research Hospital, Memphis) and Parker (University of Colorado) have based their model on a synthesis of findings from their collaborations and recent work by their individual research groups.

Research on neuronal RNA regulation in Professor Ramaswami's lab is funded by Science Foundation Ireland and benefits from collaborations with the National Centre for Biological Sciences Bangalore.


Story Source:

The above story is based on materials provided by Trinity College Dublin. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mani Ramaswami, J.Paul Taylor, Roy Parker. Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders. Cell, 2013; 154 (4): 727 DOI: 10.1016/j.cell.2013.07.038

Cite This Page:

Trinity College Dublin. "Molecular explanation for degenerative disease proposed." ScienceDaily. ScienceDaily, 16 August 2013. <www.sciencedaily.com/releases/2013/08/130816094641.htm>.
Trinity College Dublin. (2013, August 16). Molecular explanation for degenerative disease proposed. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2013/08/130816094641.htm
Trinity College Dublin. "Molecular explanation for degenerative disease proposed." ScienceDaily. www.sciencedaily.com/releases/2013/08/130816094641.htm (accessed September 15, 2014).

Share This



More Health & Medicine News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
Contagious Respiratory Illness Continues to Spread Across U.S.

Contagious Respiratory Illness Continues to Spread Across U.S.

Reuters - US Online Video (Sep. 12, 2014) Hundreds of children in several states have been stricken by a serious respiratory illness that is spreading across the U.S. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Batters Sierra Leone Economy Too

Ebola Batters Sierra Leone Economy Too

Reuters - Business Video Online (Sep. 12, 2014) The World Health Organisation warns that local health workers in West Africa can't keep up with Ebola - and among those countries hardest hit by the outbreak, the economic damage is coming into focus, too. As David Pollard reports, Sierra Leone admits that growth in one of the poorest economies in the region is taking a beating. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins