Featured Research

from universities, journals, and other organizations

Stem cell transplants may be a novel treatment for schizophrenia

Date:
September 9, 2013
Source:
University of Texas Health Science Center at San Antonio
Summary:
Researchers have discovered that transplanting stem cells into the rat brain -- into a center called the hippocampus -- restored functions that are abnormal in schizophrenia.

Daniel Lodge, Ph.D., and Stephanie Perez, doctoral student, both from the School of Medicine at the University of Texas Health Science Center at San Antonio, discovered that transplanting stem cells into the rat brain -- into a center called the hippocampus -- restored functions that are abnormal in schizophrenia.
Credit: The University of Texas Health Science Center at San Antonio

Research from the School of Medicine at The University of Texas Health Science Center at San Antonio suggests the exciting possibility of using cell transplants to treat schizophrenia.

Cells called "interneurons" inhibit activity within brain regions, but this braking or governing function is impaired in schizophrenia. Consequently, a group of nerve cells called the dopamine system go into overdrive. Different branches of the dopamine system are involved in cognition, movement and emotions.

"Since these cells are not functioning properly, our idea is to replace them," said study senior author Daniel Lodge, Ph.D., assistant professor of pharmacology in the School of Medicine.

Transplant restored normal function

Dr. Lodge and lead author Stephanie Perez, graduate student in his laboratory, biopsied tissue from rat fetuses, isolated cells from the tissue and injected the cells into a brain center called the hippocampus. This center regulates the dopamine system and plays a role in learning, memory and executive functions such as decision making. Rats treated with the transplanted cells have restored hippocampal and dopamine function.

Stem cells are able to become different types of cells, and in this case interneurons were selected. "We put in a lot of cells and not all survived, but a significant portion did and restored hippocampal and dopamine function back to normal," Dr. Lodge said.

'You can essentially fix the problem'

Unlike traditional approaches to treating schizophrenia, such as medications and deep-brain stimulation, transplantation of interneurons potentially can produce a permanent solution. "You can essentially fix the problem," Dr. Lodge said. "Ultimately, if this is translated to humans, we want to reprogram a patient's own cells and use them."

After meeting with other students, Perez brought the research idea to Dr. Lodge. "The students have journal club, and somebody had done a similar experiment to restore motor deficits and had good results," Perez said. "We thought, why can't we use it for schizophrenia and have good results, and so far we have."


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at San Antonio. Note: Materials may be edited for content and length.


Journal Reference:

  1. S M Perez, D J Lodge. Hippocampal interneuron transplants reverse aberrant dopamine system function and behavior in a rodent model of schizophrenia. Molecular Psychiatry, 2013; DOI: 10.1038/mp.2013.111

Cite This Page:

University of Texas Health Science Center at San Antonio. "Stem cell transplants may be a novel treatment for schizophrenia." ScienceDaily. ScienceDaily, 9 September 2013. <www.sciencedaily.com/releases/2013/09/130909152958.htm>.
University of Texas Health Science Center at San Antonio. (2013, September 9). Stem cell transplants may be a novel treatment for schizophrenia. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2013/09/130909152958.htm
University of Texas Health Science Center at San Antonio. "Stem cell transplants may be a novel treatment for schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2013/09/130909152958.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins