Featured Research

from universities, journals, and other organizations

Epigenetic changes observed in blood may point to early stages in Parkinson disease

Date:
September 25, 2013
Source:
Landes Bioscience
Summary:
Researchers have now shown that a distinctive pattern of epigenetic modifications is observed in specific genes associated with Parkinson Disease. Even more interesting, these changes could be easily analyzed in blood samples from patients, which appear to replicate the "epigenetic status" of brain tissue cells, potentially simplifying early diagnosis of the disease.

Parkinson disease, a neurodegenerative disorder in which both genetic and environmental factors play important roles, has been associated with epigenetic changes (those molecular modifications that alter the behavior of genes without changing the DNA sequence). Because accurate diagnosis is not easy for this disease, scientists are continuously trying to identify early signs of the disease that enable treatment before major neurological damage occurs.

In an article published in the October issue of Epigenetics, those epigenetic changes appear to be great candidates as early stage biomarkers for Parkinson Disease.

Researchers from UCSD have now shown that a distinctive pattern of epigenetic modifications (in this case called DNA methylation) is observed in specific genes associated with the disease. Even more interesting, these changes could be easily analyzed in blood samples from patients, which appear to replicate the "epigenetic status" of brain tissue cells, potentially simplifying early diagnosis of the disease.


Story Source:

The above story is based on materials provided by Landes Bioscience. Note: Materials may be edited for content and length.


Journal Reference:

  1. Eliezer Masliah, Wilmar Dumaop, Douglas Galasko, Paula Desplats. Distinctive patterns of DNA methylation associated with Parkinson disease: Identification of concordant epigenetic changes in brain and peripheral blood leukocytes. Epigenetics, 2013; 8 (10) DOI: 10.4161/epi.25865

Cite This Page:

Landes Bioscience. "Epigenetic changes observed in blood may point to early stages in Parkinson disease." ScienceDaily. ScienceDaily, 25 September 2013. <www.sciencedaily.com/releases/2013/09/130925092235.htm>.
Landes Bioscience. (2013, September 25). Epigenetic changes observed in blood may point to early stages in Parkinson disease. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2013/09/130925092235.htm
Landes Bioscience. "Epigenetic changes observed in blood may point to early stages in Parkinson disease." ScienceDaily. www.sciencedaily.com/releases/2013/09/130925092235.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins