Featured Research

from universities, journals, and other organizations

Human skin wound dressings to treat cutaneous ulcers

Date:
October 2, 2013
Source:
Université Laval
Summary:
Researchers have shown that it is possible to treat venous ulcers unresponsive to conventional treatment with wound dressings made from human skin grown in vitro. A study demonstrates how this approach was successfully used to treat venous lower-extremity ulcers in patients who had been chronically suffering from such wounds.

Researchers from Université Laval's Faculty of Medicine and CHU de Québec have shown that it is possible to treat venous ulcers unresponsive to conventional treatment with wound dressings made from human skin grown in vitro. A study published recently in the journal Advances in Skin and Wound Care demonstrates how this approach was successfully used to treat venous lower-extremity ulcers in patients who had been chronically suffering from such wounds.

About 1% of the population suffers from lower-extremity ulcers. These wounds regularly become inflamed or infected and are very slow to heal, if they do at all. They are frequently associated with aging, diabetes, and circulatory system disorders such as varicose veins and oedema. "Obese individuals and those who work constantly standing up are especially vulnerable. These ulcers can persist for years. It can be a hellish clinical situation when standard treatments don't work," noted Dr. François A. Auger, director of both the study and LOEX, the tissue engineering and regenerative medicine laboratory where it was conducted.

Standard treatment for ulcers involves methodically cleaning these wounds and applying compression bandages. Drugs became available around 20 years ago but they are expensive and their efficacy has been somewhat limited. A graft using the patient's own skin can be effective but is problematic because it requires a significant amount of skin to be removed from elsewhere on the body.

This very problem inspired LOEX researchers to use their expertise with in vitro skin culture to create biomaterial-free biological wound dressing. The process is complex and requires several steps: removing 1 cm2 of skin from the patient, isolating the appropriate cells, growing them in vitro, and creating a skin substitute with both dermis and epidermis. After eight weeks of growth the self-assembled sheets of skin substitute can be applied over the ulcers, much like bandages, and replaced weekly as long as necessary. "This totally biological bandage is much more than a physical barrier," stresses Dr. Auger. "The cells secrete molecules that speed up healing by helping to set natural healing processes in motion. It would be hard to imagine a model closer to the human body's natural physiology."

Tests were successfully carried out on five patients. It took only an average of seven weeks to cure 14 ulcers that had been affecting patients for at least six months, and in some cases, several years. "This is a last recourse once all other treatment options have been exhausted," notes François A. Auger.

Dr. Auger sees another promising application for these biological bandages: "We have shown that this is effective for patients with leg ulcers. Now, we intend to carry out a clinical study to demonstrate that the same treatment works for patients with serious burns, as soon as we get the necessary approvals."


Story Source:

The above story is based on materials provided by Université Laval. Note: Materials may be edited for content and length.


Journal Reference:

  1. Olivier Boa, Chanel Beaudoin Cloutier, Hervé Genest, Raymond Labbé, Bertrand Rodrigue, Jacques Soucy, Michel Roy, Frédéric Arsenault, Carlos E. Ospina, Nathalie Dubé, Marie-Hélène Rochon, Danielle Larouche, Véronique J. Moulin, Lucie Germain, François A. Auger. Prospective Study on the Treatment of Lower-Extremity Chronic Venous and Mixed Ulcers Using Tissue-Engineered Skin Substitute Made by the Self-assembly Approach. Advances in Skin & Wound Care, 2013; 26 (9): 400 DOI: 10.1097/01.ASW.0000433102.48268.2a

Cite This Page:

Université Laval. "Human skin wound dressings to treat cutaneous ulcers." ScienceDaily. ScienceDaily, 2 October 2013. <www.sciencedaily.com/releases/2013/10/131002185656.htm>.
Université Laval. (2013, October 2). Human skin wound dressings to treat cutaneous ulcers. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2013/10/131002185656.htm
Université Laval. "Human skin wound dressings to treat cutaneous ulcers." ScienceDaily. www.sciencedaily.com/releases/2013/10/131002185656.htm (accessed August 28, 2014).

Share This




More Mind & Brain News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) — Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com
Alice in Wonderland Syndrome

Alice in Wonderland Syndrome

Ivanhoe (Aug. 27, 2014) — It’s an unusual condition with a colorful name. Kids with “Alice in Wonderland” syndrome see sudden distortions in objects they’re looking at or their own bodies appear to change size, a lot like the main character in the Lewis Carroll story. Video provided by Ivanhoe
Powered by NewsLook.com
Stopping Schizophrenia Before Birth

Stopping Schizophrenia Before Birth

Ivanhoe (Aug. 27, 2014) — Scientists have long called choline a “brain booster” essential for human development. Not only does it aid in memory and learning, researchers now believe choline could help prevent mental illness. Video provided by Ivanhoe
Powered by NewsLook.com
Personalized Brain Vaccine for Glioblastoma

Personalized Brain Vaccine for Glioblastoma

Ivanhoe (Aug. 27, 2014) — Glioblastoma is the most common and aggressive brain cancer in humans. Now a new treatment using the patient’s own tumor could help slow down its progression and help patients live longer. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins