Featured Research

from universities, journals, and other organizations

Genetic variation alters efficacy of antidepressant

Date:
October 22, 2013
Source:
Society for Neuroscience
Summary:
Having a different form of a gene that regulates the brain chemical noradrenaline influences how well men remember negative memories after taking the antidepressant drug reboxetine, according to a study. The findings demonstrate how genes can influence antidepressant response.

Having a different form of a gene that regulates the brain chemical noradrenaline influences how well men remember negative memories after taking the antidepressant drug reboxetine, according to a study published in the October 23 issue of The Journal of Neuroscience. The findings demonstrate how genes can influence antidepressant response.

While it is normal for our strongest memories to be associated with emotional experiences, previous studies suggest the heightened recall of negative events may be linked to depression and anxiety disorders. Research also shows that reboxetine, which exclusively affects brain levels of noradrenaline, reduces the tendency of people with depression to recall negative memories.

In the current study, Ayana Gibbs, MD, PhD, Theodora Duka, MD, PhD, and others at the University of Sussex examined how reboxetine influences emotional memories in healthy men with a variant form of the α-2B adrenoceptor gene (ADRA2B), which contains the instructions for a type of noradrenaline receptor. The researchers found that while reboxetine weakened aversive memory in people with the common form of ADRA2B, the drug did not change aversive memory in people with the variant gene form.

"Researchers are increasingly interested in how antidepressants like reboxetine affect the way emotional information is processed and how this information could be used to predict the drugs that are most likely to be successful antidepressants," Gibbs said. "Our study suggests genetic makeup is another important piece of the puzzle."

More than 100 healthy white men participated in the University of Sussex study, where they received a genetic test to see if they had the ADRA2B variant (30 percent of whites do). They were then randomly assigned to receive a single dose of reboxetine or a sugar (placebo) pill. After waiting a couple of hours for the drug to be absorbed into the bloodstream, the men viewed a series of positive, negative, and neutral images on a computer screen. Such images included pictures of children riding a rollercoaster ride, the scene of an accident, and a man looking out of a window. Thirty minutes later, they were asked to write descriptions of as many pictures as they could remember.

While all participants remembered the positive and negative pictures better than the neutral ones, the participants with the ADRA2B variant recalled more negative pictures -- an effect that remained even in those who received the reboxetine treatment.

"This study is good news for the scientific community, which has struggled for decades to identify factors influencing the admittedly moderate efficacy of antidepressants," explained Andreas Papassotiropoulos, MD, who studies how genes influence memory at the University of Basel and was not involved with this study. "This study elegantly demonstrates the importance of the concept of aversive memory in psychiatric disease and paves the way for further experiments dealing with the molecular underpinnings of antidepressant efficacy," he added.

According to Gibbs, future studies will explore whether the ADRA2B variant influences the effectiveness of reboxetine in other groups, including women, and establish whether similar effects are observed in patients with depression or anxiety disorders.


Story Source:

The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. A. Gibbs, C. E. Bautista, F. D. Mowlem, K. H. Naudts, T. Duka. Alpha 2B Adrenoceptor Genotype Moderates Effect of Reboxetine on Negative Emotional Memory Bias in Healthy Volunteers. Journal of Neuroscience, 2013; 33 (43): 17023 DOI: 10.1523/JNEUROSCI.2124-13.2013

Cite This Page:

Society for Neuroscience. "Genetic variation alters efficacy of antidepressant." ScienceDaily. ScienceDaily, 22 October 2013. <www.sciencedaily.com/releases/2013/10/131022183250.htm>.
Society for Neuroscience. (2013, October 22). Genetic variation alters efficacy of antidepressant. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2013/10/131022183250.htm
Society for Neuroscience. "Genetic variation alters efficacy of antidepressant." ScienceDaily. www.sciencedaily.com/releases/2013/10/131022183250.htm (accessed October 22, 2014).

Share This



More Mind & Brain News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
Portable Breathalyzer Gets You Home Safely

Portable Breathalyzer Gets You Home Safely

Buzz60 (Oct. 21, 2014) Breeze, a portable breathalyzer, gets you home safely by instantly showing your blood alcohol content, and with one tap, lets you call an Uber, a cab or a friend from your contact list to pick you up. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Your Birth Season Might Determine Your Temperament

Your Birth Season Might Determine Your Temperament

Newsy (Oct. 20, 2014) A new study says the season you're born in can determine your temperament — and one season has a surprising outcome. Video provided by Newsy
Powered by NewsLook.com
Movies Might Desensitize Violence For Parents, Not Just Kids

Movies Might Desensitize Violence For Parents, Not Just Kids

Newsy (Oct. 20, 2014) A study suggests that parents become desensitized to violent movies as well as children, which leads them to allow their kids to view violent films. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins