Featured Research

from universities, journals, and other organizations

Healing powers of cells

Date:
November 13, 2013
Source:
Institute of Science and Technology Austria
Summary:
How do cells spread to cover and close a wound? A team of researchers publishes new insights into epithelial cell spreading.

The image depicts a small region of the zebrafish Enveloping Layer (EVL), the early embryonic skin made of squamous epithelial cells.
Credit: Heisenberg Group

How do cells spread to cover and close a wound? A team of researchers led by IST Austria Professor Carl-Philipp Heisenberg, including first author Pedro Campinho, PhD student in the Heisenberg group, publishes new insights into epithelial cell spreading in the current online edition of Nature Cell Biology.

Spreading of the epithelial cell layer is fundamental for epithelial closure and wound healing, as well as for embryonic development. The challenge presented here is that the cell layer needs to increase in surface area, but nevertheless maintain its integrity. For their research, the Heisenberg's team used the process of epiboly in zebrafish development to model cell spreading. Epiboly is a step in the embryonic development of zebrafish during which a thin epithelial cell layer spreads over the entire cell sphere within a space of only 6 hours. This fast cell spreading comes along with a rapid increase of the epithelium's surface area, and a build-up of tension in the cell layer.

The researchers found a new mechanism required for releasing the built-up tension, namely orienting the direction in which cells divide through mechanical tension. They show that controlling this mechanism requires two processes, namely cell elongation and the correct alignment of the mitotic spindle, the cell's control center for division. The tension in the epithelium elongates the cells. As cells usually orient their spindle along the longest axis, this results in cells dividing perpendicular to the long axis. In addition, myosin II activity aligns the mitotic spindle with the axis of tension.

In the absence of tension-oriented cell division, tissue tension is increased, and the researchers observed an ectopic fusion of cells as an alternative mechanism of tension release. They conclude that cell-division orientation by tension is a key mechanism for limiting the tension arising during epithelial spreading, thereby ensuring tissue integrity and tissue spreading during epiboly.


Story Source:

The above story is based on materials provided by Institute of Science and Technology Austria. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pedro Campinho, Martin Behrndt, Jonas Ranft, Thomas Risler, Nicolas Minc, Carl-Philipp Heisenberg. Tension-oriented cell divisions limit anisotropic tissue tension in epithelial spreading during zebrafish epiboly. Nature Cell Biology, 2013; DOI: 10.1038/ncb2869

Cite This Page:

Institute of Science and Technology Austria. "Healing powers of cells." ScienceDaily. ScienceDaily, 13 November 2013. <www.sciencedaily.com/releases/2013/11/131113105703.htm>.
Institute of Science and Technology Austria. (2013, November 13). Healing powers of cells. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2013/11/131113105703.htm
Institute of Science and Technology Austria. "Healing powers of cells." ScienceDaily. www.sciencedaily.com/releases/2013/11/131113105703.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins