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Higher than normal levels of Vitamin B12 may indicate cancer risk

Date:
November 18, 2013
Source:
Journal of the National Cancer Institute
Summary:
Vitamin B12 (cobalamin [Cbl]) is essential for maintaining healthy bodily function, but higher than normal levels (reference range 200-600 pmol/L) may indicate that a patient is at risk of developing certain cancers, according to a study published. Previous studies had suggested an association between high Cbl levels and specific cancers.
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Vitamin B12 (cobalamin [Cbl]) is essential for maintaining healthy bodily function but higher than normal levels (reference range 200-600 pmol/L) may indicate that a patient is at risk of developing certain cancers, according to a study published November 18 in the Journal of the National Cancer Institute. Previous studies had suggested an association between high Cbl levels and specific cancers.

To assess the association between high Cbl levels and risk of cancer of any type, Johan Arendt, BSc, of the Department of Clinical Epidemiology and the Department of Clinical Biochemistry of Aarhus University Hospital in Denmark, and colleagues used Danish Medical registries to review the records of 333,667 patients without cancer who had been referred for Cbl testing and to estimate the incidence of cancer in this population from 1998 to 2010.

The researchers excluded patients who had a cancer diagnosis before the date of plasma measurement and those who were receiving Cbl therapy. They found that the risk of cancer overall increased with higher Cbl levels, especially during the first year after measurement and for those with levels > 800pmol/L. They also found that after five years of follow-up, the risk for hematological and alcohol and smoking-related cancers remained high for those with levels > 800pmol/L.

The authors conclude that "…high plasma Cbl levels increased the risk of subsequently diagnosed cancer, mostly within the first year of follow-up." However, Arendt et al. note that high plasma Cbl levels are probably not related to normal Vitamin B12 intake because consumption of Cbl containing foods or supplements do not increase plasma Cbl levels substantially. Rather, high Cbl levels may result from some unknown malignant process.


Story Source:

The above post is reprinted from materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. F. B. Arendt, L. Pedersen, E. Nexo, H. T. Sorensen. Elevated Plasma Vitamin B12 Levels as a Marker for Cancer: A Population-Based Cohort Study. JNCI Journal of the National Cancer Institute, 2013; DOI: 10.1093/jnci/djt315

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Journal of the National Cancer Institute. "Higher than normal levels of Vitamin B12 may indicate cancer risk." ScienceDaily. ScienceDaily, 18 November 2013. <www.sciencedaily.com/releases/2013/11/131118162805.htm>.
Journal of the National Cancer Institute. (2013, November 18). Higher than normal levels of Vitamin B12 may indicate cancer risk. ScienceDaily. Retrieved August 1, 2015 from www.sciencedaily.com/releases/2013/11/131118162805.htm
Journal of the National Cancer Institute. "Higher than normal levels of Vitamin B12 may indicate cancer risk." ScienceDaily. www.sciencedaily.com/releases/2013/11/131118162805.htm (accessed August 1, 2015).

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