Featured Research

from universities, journals, and other organizations

Different cellular mechanisms behind regenerated body parts

Date:
November 21, 2013
Source:
Karolinska Institutet
Summary:
Scientists have discovered that two separate species of salamander differ in the way their muscles grow back in lost body parts. Their findings on the species-specific solutions demonstrate there is more than one mechanism of tissue regeneration.

Scientists at Karolinska Institutet have discovered that two separate species of salamander differ in the way their muscles grow back in lost body parts. Their findings on the species-specific solutions, published in the scientific periodical Cell Stem Cell, demonstrate there is more than one mechanism of tissue regeneration.

Related Articles


To carry out their study, the scientists labelled different cell types in two species of salamander in order to ascertain what kinds of cell give rise to new muscle tissue in salamanders that had lost a front leg. Salamanders are known for their remarkable ability to regenerate not only lost tails and other extremities but also the tissue of internal organs, such as the heart and brain. The traditional view is that the new tissue is formed from a population of stem cells activated when body parts are damaged; what they found, however, was that even though the two species were relatively closely related, this was true only for one.

"We show that in one of the salamander species, muscle tissue is regenerated from specialised muscle cells that dedifferentiate and forget what type of cell they've been," says principal investigator Dr Andrαs Simon at the Department of Cell and Molecular Biology. "This is an interesting cellular mechanism that destabilises cell specialisation and produces new stem cells, as opposed to the other species, in which the new muscles are created from existing stem cells."

In the dedifferentiating species, the capacity to regenerate tissue does not decline with age, which the scientists believe can be linked to their ability to make new stem cells from muscle cells on demand. Human muscle is also regenerative, and damaged fibres are repaired effectively. However, in patients with muscular dystrophy (a group of disorders in which the muscles are gradually broken down), for instance, the body eventually cannot keep up with the loss of muscle tissue. A possible reason for this is that the number of functional muscle stem cells in these patients decreases over time, leaving the population too small to repair the damage. The findings from the salamanders are not yet applicable to humans, but the knowledge gained will one day help scientists understand how damaged or lost tissue is regenerated.

"It's important to study the process by which the salamander's muscle cells forget their cellular identity and how it s modulated," says Dr Simon. "It's also important to examine why their ability to regenerate is independent of age and the number of times the same tissue and body part has been regenerated."


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tatiana Sandoval-Guzmαn, Heng Wang3, Shahryar Khattak, Maritta Schuez, Kathleen Roensch, Eugeniu Nacu, Akira Tazaki, Alberto Joven, Elly M. Tanaka, Andrαs Simon. Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species. Cell Stem Cell, November 2013

Cite This Page:

Karolinska Institutet. "Different cellular mechanisms behind regenerated body parts." ScienceDaily. ScienceDaily, 21 November 2013. <www.sciencedaily.com/releases/2013/11/131121125908.htm>.
Karolinska Institutet. (2013, November 21). Different cellular mechanisms behind regenerated body parts. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2013/11/131121125908.htm
Karolinska Institutet. "Different cellular mechanisms behind regenerated body parts." ScienceDaily. www.sciencedaily.com/releases/2013/11/131121125908.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) — Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
Birds Might Be Better Meteorologists Than Us

Birds Might Be Better Meteorologists Than Us

Newsy (Dec. 19, 2014) — A new study suggests a certain type of bird was able to sense a tornado outbreak that moved through the U.S. a day before it hit. Video provided by Newsy
Powered by NewsLook.com
Navy Unveils Robot Fish

Navy Unveils Robot Fish

Reuters - Light News Video Online (Dec. 18, 2014) — The U.S. Navy unveils an underwater device that mimics the movement of a fish. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins